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| pubmed-article:17604280 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
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| pubmed-article:17604280 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17604280 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:17604280 | pubmed:dateCreated | 2007-8-20 | lld:pubmed |
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| pubmed-article:17604280 | pubmed:abstractText | A mechanism by which ubiquitinated cargo proteins are sorted into multivesicular bodies (MVBs) from plasma and trans-Golgi network (TGN) membranes is well established in yeast and mammalian somatic cells. However, the ubiquitin-dependent sorting pathway has not been clearly defined in germ cells. In this study we identified a novel member of the transmembrane RING-finger family of proteins, termed membrane-associated RING-CH (MARCH)-XI, that is expressed predominantly in developing spermatids and weakly in brain and pituitary. MARCH-XI possesses an E3 ubiquitin ligase activity that targets CD4 for ubiquitination. Immunoelectron microscopy of rat round spermatids showed that MARCH-XI is localized to TGN-derived vesicles and MVBs. Fluorescence staining of rat round spermatids and immunoprecipitation of rat testis demonstrated that MARCH-XI forms complexes with the adaptor protein complex-1 and with fucose-containing glycoproteins including ubiquitinated forms. Furthermore, the C-terminal region of MARCH-XI mediates its interaction with mu1-adaptin and Veli through a tyrosine-based motif and a PDZ binding motif, respectively. Our data suggest that MARCH-XI acts as a ubiquitin ligase with a role in ubiquitin-mediated protein sorting in the TGN-MVB transport pathway, which may be involved in mammalian spermiogenesis. | lld:pubmed |
| pubmed-article:17604280 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17604280 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17604280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17604280 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17604280 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:HirataYukioY | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:YamamotoYokoY | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:YamashinaShoh... | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:HiroseShigehi... | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:KatoAkiraA | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:NakamuraNobuh... | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:SakaiYasuhiro... | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:NotoyaMichita... | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:MorokumaYuriY | lld:pubmed |
| pubmed-article:17604280 | pubmed:author | pubmed-author:FukudaHidekaz... | lld:pubmed |
| pubmed-article:17604280 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17604280 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:17604280 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:17604280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17604280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17604280 | pubmed:pagination | 24806-15 | lld:pubmed |
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| pubmed-article:17604280 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17604280 | pubmed:articleTitle | MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. | lld:pubmed |
| pubmed-article:17604280 | pubmed:affiliation | Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226-8501, Japan. | lld:pubmed |
| pubmed-article:17604280 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17604280 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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