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pubmed-article:17595888pubmed:abstractTextApplication-site disorders are well-known adverse events (AEs) associated with subcutaneous (s.c.) injection. With high-dose, high-frequency interferon (IFN)-beta1a (Rebif) these AEs are generally mild but may lead to the discontinuation of some patients. The objective of this study was to compare the safety, tolerability, and the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of two new formulations of Rebif (Rebif New Formulation: RNF1 and RNF2) with the current formulation (hereafter referred to as R) and placebo.lld:pubmed
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pubmed-article:17595888pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:17595888pubmed:year2007lld:pubmed
pubmed-article:17595888pubmed:articleTitleAssessment of the safety, tolerability, and PK/PD properties of two new formulations of subcutaneously administered IFN-beta1a: a double-blind, placebo-controlled comparison with the currently available formulation.lld:pubmed
pubmed-article:17595888pubmed:affiliationMerck Serono International S.A., Geneva, Switzerland.lld:pubmed
pubmed-article:17595888pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17595888pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17595888pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:17595888pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed