| pubmed-article:17590174 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17590174 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17590174 | lifeskim:mentions | umls-concept:C0020861 | lld:lifeskim |
| pubmed-article:17590174 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:17590174 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:17590174 | lifeskim:mentions | umls-concept:C0971858 | lld:lifeskim |
| pubmed-article:17590174 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17590174 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17590174 | pubmed:dateCreated | 2007-8-16 | lld:pubmed |
| pubmed-article:17590174 | pubmed:abstractText | IgM is one major type of B cell receptor (BCR) expressed on most of the B cells from immature to mature stages. During normal B cell ontogeny, signals transduced through the IgM BCR play an important role in regulating B cell maturation and survival at multiple checkpoints. In addition, IgM BCR is also required for antigen-dependent differentiation and activation of B cells. However, whether IgM BCR-mediated signalling is important for the pathogenesis of autoimmune diseases remains elusive. Using IgM-deficient mice, we examined the effect of absence of IgM on the development of collagen-induced arthritis (CIA), an animal model of rheumatoid arthritis (RA). Compared to their wild-type littermates, IgM-deficient mice were either resistant to arthritis induction or developed significantly less severe arthritis. There was a significant decrease of autoantibody production in IgM-deficient mice, particularly IgG2a antibodies, which is believed to be pathogenic in CIA. Thus, although IgM(-/-) mice have relatively normal B cell development with IgD BCR replacing IgM BCR, the absence of IgM-mediated signals has a profound impact on the development of CIA, indicating that IgM plays an important role in the development and pathogenesis of autoimmune arthritis and IgM-mediated signalling is critical in the generation of pathogenic autoreactive antibodies. | lld:pubmed |
| pubmed-article:17590174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17590174 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17590174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590174 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17590174 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17590174 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:17590174 | pubmed:author | pubmed-author:YUH IHI | lld:pubmed |
| pubmed-article:17590174 | pubmed:author | pubmed-author:HamRR | lld:pubmed |
| pubmed-article:17590174 | pubmed:author | pubmed-author:ZhangXX | lld:pubmed |
| pubmed-article:17590174 | pubmed:author | pubmed-author:ZhengBB | lld:pubmed |
| pubmed-article:17590174 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17590174 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:17590174 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17590174 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17590174 | pubmed:pagination | 579-85 | lld:pubmed |
| pubmed-article:17590174 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:meshHeading | pubmed-meshheading:17590174... | lld:pubmed |
| pubmed-article:17590174 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17590174 | pubmed:articleTitle | IgM plays an important role in induction of collagen-induced arthritis. | lld:pubmed |
| pubmed-article:17590174 | pubmed:affiliation | Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:17590174 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17590174 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16019 | entrezgene:pubmed | pubmed-article:17590174 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17590174 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17590174 | lld:pubmed |
