| pubmed-article:17585360 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C1332708 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17585360 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17585360 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17585360 | pubmed:dateCreated | 2007-9-17 | lld:pubmed |
| pubmed-article:17585360 | pubmed:abstractText | B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of patients with RA. Thirty-two RA patients and 16 controls were enrolled in this study, and CD22 expressions on B cells were analyzed by flow cytometry. In patients with RA, CD22(+) B cells significantly decreased in comparison to the controls (ratio: P < 0.05). However, there was no correlation between this decrease and the clinical data. Interestingly, CD5(+) CD22(-) B cells significantly increased in RA patients. The decrease in CD22(+) B cells and increased in CD5(+)CD22(-) B cells play critical roles in the pathogenesis of RA mediated by the activation of B cells. | lld:pubmed |
| pubmed-article:17585360 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17585360 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17585360 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17585360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17585360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17585360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17585360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17585360 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17585360 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17585360 | pubmed:issn | 0770-3198 | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:SuzukiJunJ | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:TakasakiYoshi... | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:TokanoYoshiak... | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:AmanoHirofumi... | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:MorimotoShinj... | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:MitsuoAkikoA | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:NakiriYutakaY | lld:pubmed |
| pubmed-article:17585360 | pubmed:author | pubmed-author:MinowaKentaro... | lld:pubmed |
| pubmed-article:17585360 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17585360 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17585360 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17585360 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17585360 | pubmed:pagination | 1721-3 | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:meshHeading | pubmed-meshheading:17585360... | lld:pubmed |
| pubmed-article:17585360 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17585360 | pubmed:articleTitle | Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells. | lld:pubmed |
| pubmed-article:17585360 | pubmed:affiliation | Department of Rheumatology and Internal Medicine, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. mayuta@hkg.odn.ne.jp | lld:pubmed |
| pubmed-article:17585360 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:933 | entrezgene:pubmed | pubmed-article:17585360 | lld:entrezgene |
| entrez-gene:921 | entrezgene:pubmed | pubmed-article:17585360 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17585360 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17585360 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17585360 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17585360 | lld:pubmed |
