| pubmed-article:17579662 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17579662 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17579662 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:17579662 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:17579662 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:17579662 | lifeskim:mentions | umls-concept:C0288250 | lld:lifeskim |
| pubmed-article:17579662 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:17579662 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17579662 | pubmed:dateCreated | 2007-8-23 | lld:pubmed |
| pubmed-article:17579662 | pubmed:abstractText | The kidney is the major regulator of potassium homeostasis. In addition to the ROMK channels, large conductance Ca(2+)-activated K(+) (BK) channels are expressed in the apical membrane of the aldosterone sensitive distal nephron where they could contribute to renal K(+) secretion. We studied flow-induced K(+) secretion in BK channel alpha-subunit knockout (BK(-/-)) mice by acute pharmacologic blockade of vasopressin V(2) receptors, which caused similar diuresis in wild-type and knockout mice. However, wild-type mice, unlike the BK(-/-), had a concomitant increase in urinary K(+) excretion and a significant correlation between urinary flow rate and K(+) excretion. Both genotypes excreted similar urinary amounts of K(+) irrespective of K(+) diet. This was associated, however, with higher plasma aldosterone and stronger expression of ROMK in the apical membrane of the aldosterone-sensitive portions of the distal nephron in the knockout than in the wild-type under control diet and even more so with the high-K(+) diet. High-K(+) intake significantly increased the renal expression of the BK channel in the wild-type mouse. Finally, despite the higher plasma K(+) and aldosterone levels, BK(-/-) mice restrict urinary K(+) excretion when placed on a low-K(+) diet to the same extent as the wild-type. These studies suggest a role of the BK channel alpha-subunit in flow-induced K(+) secretion and in K(+) homeostasis. Higher aldosterone and an upregulation of ROMK may compensate for the absence of functional BK channels. | lld:pubmed |
| pubmed-article:17579662 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17579662 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17579662 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17579662 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17579662 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17579662 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17579662 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17579662 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17579662 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:17579662 | pubmed:author | pubmed-author:OsswaldHH | lld:pubmed |
| pubmed-article:17579662 | pubmed:author | pubmed-author:KaisslingBB | lld:pubmed |
| pubmed-article:17579662 | pubmed:author | pubmed-author:RussDD | lld:pubmed |
| pubmed-article:17579662 | pubmed:author | pubmed-author:RiemRR | lld:pubmed |
| pubmed-article:17579662 | pubmed:author | pubmed-author:VallonVV | lld:pubmed |
| pubmed-article:17579662 | pubmed:author | pubmed-author:SausbierMM | lld:pubmed |
| pubmed-article:17579662 | pubmed:author | pubmed-author:SausbierUU | lld:pubmed |
| pubmed-article:17579662 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17579662 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:17579662 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17579662 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17579662 | pubmed:pagination | 566-73 | lld:pubmed |
| pubmed-article:17579662 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:17579662 | pubmed:meshHeading | pubmed-meshheading:17579662... | lld:pubmed |
| pubmed-article:17579662 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17579662 | pubmed:articleTitle | The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion. | lld:pubmed |
| pubmed-article:17579662 | pubmed:affiliation | Institute of Pharmacology and Toxicology, Medical Faculty of the Eberhard Karls University, Wilhelmstrasse 56, 72074 Tübingen, Germany. | lld:pubmed |
| pubmed-article:17579662 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17579662 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16531 | entrezgene:pubmed | pubmed-article:17579662 | lld:entrezgene |
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