| pubmed-article:17575075 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C0041296 | lld:lifeskim |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C0165519 | lld:lifeskim |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:17575075 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:17575075 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17575075 | pubmed:dateCreated | 2007-9-17 | lld:pubmed |
| pubmed-article:17575075 | pubmed:abstractText | Mycobacterium tuberculosis (MTb) kills approximately 2 million people each year. MTb must drive host tissue destruction to disseminate and also to cause pulmonary cavitation. Matrix metalloproteinase-9 (MMP-9, gelatinase B) is implicated in this Tb-related immunopathology. We demonstrate that conditioned media from MTb-infected monocytes (CoMTb), but not direct infection with MTb, up-regulates MMP-9 gene expression and secretion from primary human bronchial epithelial cells (NHBE). MMP-9 secretion was increased 8.7-fold by CoMTb (P < 0.05) as assayed by gelatin zymography. A549 and 16HBE14o epithelial cell MMP secretion was significantly less than primary NHBE secretion. MMP-9 secretion was decreased 53.2% by inhibition of the p38 mitogen-activated protein kinase (MAPK) by SB203580 (P < 0.01) and 48.3% by inhibition of extracellular signal-regulated kinase with PD98059 (P < 0.05). MMP-9 secretion was prostaglandin independent. TNF-alpha was necessary but not sufficient for MMP-9 up-regulation by the monocyte-epithelial cell network. Soluble factors derived from Tb culture synergized with TNF-alpha to increase MMP-9 secretion by NHBE 6-fold (P < 0.01 compared with either stimulus alone). Together, these data reveal a new mechanism by which host- and pathogen-derived factors act together in MTb infection to drive MAPK-dependent MMP-9 secretion from respiratory epithelial cells. | lld:pubmed |
| pubmed-article:17575075 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17575075 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17575075 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17575075 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17575075 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:17575075 | pubmed:author | pubmed-author:FriedlandJon... | lld:pubmed |
| pubmed-article:17575075 | pubmed:author | pubmed-author:BoyleJoseph... | lld:pubmed |
| pubmed-article:17575075 | pubmed:author | pubmed-author:GreenJustin... | lld:pubmed |
| pubmed-article:17575075 | pubmed:author | pubmed-author:O'KaneCecilia... | lld:pubmed |
| pubmed-article:17575075 | pubmed:author | pubmed-author:EmersonJenny... | lld:pubmed |
| pubmed-article:17575075 | pubmed:author | pubmed-author:ElkingtonPaul... | lld:pubmed |
| pubmed-article:17575075 | pubmed:author | pubmed-author:Lopez-PascuaL... | lld:pubmed |
| pubmed-article:17575075 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17575075 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:17575075 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17575075 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17575075 | pubmed:pagination | 431-7 | lld:pubmed |
| pubmed-article:17575075 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17575075 | pubmed:meshHeading | pubmed-meshheading:17575075... | lld:pubmed |
| pubmed-article:17575075 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17575075 | pubmed:articleTitle | Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis. | lld:pubmed |
| pubmed-article:17575075 | pubmed:affiliation | Department of Infectious Diseases, Imperial College, Hammersmith Hospital, London, UK. | lld:pubmed |
| pubmed-article:17575075 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17575075 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4318 | entrezgene:pubmed | pubmed-article:17575075 | lld:entrezgene |
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| lhgdn:association:10692 | lhgdn:found_in | pubmed-article:17575075 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575075 | lld:pubmed |
