| pubmed-article:17572495 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17572495 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17572495 | lifeskim:mentions | umls-concept:C0812299 | lld:lifeskim |
| pubmed-article:17572495 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:17572495 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:17572495 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17572495 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17572495 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17572495 | pubmed:dateCreated | 2007-9-28 | lld:pubmed |
| pubmed-article:17572495 | pubmed:abstractText | Fra-1 is overexpressed in a variety of human tumors. Whether MMP-9 expression is regulated by Fra-1 has been contradictory. To clarify the capability of Fra-1 in activating transcription of MMP-9 gene, we analyzed the transcriptional activity of the MMP-9 promoter through the measure of luciferase activities in the MCF-7 cells transiently transfected with Fra-1. The positive regulation of Fra-1 on MMP-9 promoter was not detectable. By the analysis of MMP-9 promoter, a potential Stat3 binding site, just juxtaposed AP-1 consensus sequence, was noticed. The reporter assay showed that MMP-9 promoter was activated remarkably by cotransfection with Fra-1 and Stat3C. DNA affinity precipitation assay confirmed the binding of Stat3 and Fra-1 to the elements of MMP-9 promoter and also revealed c-Jun recruited to Stat3-Fra-1 complex. By immunoprecipitation assay, the Stat3/Fra-1, Stat3/c-Jun and Fra-1/c-Jun complexes were identified in vivo. Our study demonstrated that the activation of MMP-9 promoter is dependent upon interactions of Fra-1/c-Jun with Stat3. A juxtaposed Stat3/AP-1 element plays a crucial role in the manner of enhancersome in the activation of MMP-9 gene. The functional cooperation of the Stat3 and AP-1 transcription factors is required for the transcription of MMP-9 gene. | lld:pubmed |
| pubmed-article:17572495 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17572495 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17572495 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17572495 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17572495 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17572495 | pubmed:issn | 0161-5890 | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:LeskDD | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:NellL JLJ | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:ZhangHaoH | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:ZhangYanY | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:YuMingM | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:SongSantaiS | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:SongYuhuaY | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:XiaQingQ | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:JiangZefeiZ | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:LuQianQ | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:HuMeiruM | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:ChenLiyongL | lld:pubmed |
| pubmed-article:17572495 | pubmed:author | pubmed-author:YuanGuogangG | lld:pubmed |
| pubmed-article:17572495 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17572495 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:17572495 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17572495 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17572495 | pubmed:pagination | 137-43 | lld:pubmed |
| pubmed-article:17572495 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17572495 | pubmed:meshHeading | pubmed-meshheading:17572495... | lld:pubmed |
| pubmed-article:17572495 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17572495 | pubmed:articleTitle | Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene. | lld:pubmed |
| pubmed-article:17572495 | pubmed:affiliation | Institute of Basic Medical Sciences, Beijing 100850, PR China. | lld:pubmed |
| pubmed-article:17572495 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17572495 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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