| pubmed-article:17569777 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C0280141 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C0038351 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:17569777 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:17569777 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17569777 | pubmed:dateCreated | 2007-7-27 | lld:pubmed |
| pubmed-article:17569777 | pubmed:abstractText | Leukemia-specific chromosome translocations involving the nucleoporin CAN/NUP214 lead to expression of different fusion genes including DEK-CAN, CAN-ABL, and SET-CAN. DEK-CAN and CAN-ABL1 are associated with acute myeloid leukemia and T-cell acute lymphoblastic leukemia, respectively, whereas SET-CAN was identified in a patient with acute undifferentiated leukemia. In addition, SET is overexpressed in solid tumors of the breast, uterus, stomach, and rectum. Ectopic expression of SET-CAN inhibits vitamin-D(3)-induced differentiation of the human promonocytic U937cells, whereas ectopic SET expression induces differentiation. Here, we assessed the leukemogenic potential of SET-CAN in the hematopoietic system of transgenic mice. Although SET-CAN mice showed expansion of an early progenitor cell pool and partial depletion of lymphocytes, the animals were not leukemia-prone and did not show shortening of disease latency after retroviral tagging. This suggests that SET-CAN expression in acute undifferentiated leukemia might determine the primitive phenotype of the disease, whereas secondary genetic lesions are necessary for disease development. Surprisingly, SET-CAN mice developed spontaneous hyperplasia of the stomach mucosa, which coincided with overexpression of beta-catenin and vastly increased numbers of proliferating gastric mucosa cells, suggesting a role of SET-CAN in proliferation of certain epithelial cells. | lld:pubmed |
| pubmed-article:17569777 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17569777 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17569777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569777 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17569777 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17569777 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:OzbekUgurU | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:FoddeRiccardo... | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:FrankenPatric... | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:GrosveldGerar... | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:BoydKelliK | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:KandilciAyten... | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:17569777 | pubmed:author | pubmed-author:BontenJacquel... | lld:pubmed |
| pubmed-article:17569777 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17569777 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:17569777 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17569777 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17569777 | pubmed:pagination | 654-66 | lld:pubmed |
| pubmed-article:17569777 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
| pubmed-article:17569777 | pubmed:meshHeading | pubmed-meshheading:17569777... | lld:pubmed |
