| pubmed-article:17569064 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17569064 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:17569064 | lifeskim:mentions | umls-concept:C0085084 | lld:lifeskim |
| pubmed-article:17569064 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:17569064 | lifeskim:mentions | umls-concept:C0751072 | lld:lifeskim |
| pubmed-article:17569064 | lifeskim:mentions | umls-concept:C1880945 | lld:lifeskim |
| pubmed-article:17569064 | lifeskim:mentions | umls-concept:C1512693 | lld:lifeskim |
| pubmed-article:17569064 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17569064 | pubmed:dateCreated | 2007-6-26 | lld:pubmed |
| pubmed-article:17569064 | pubmed:abstractText | Neurodegenerative disorders share a process of aggregation of insoluble protein. Frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) is characterized by the presence of ubiquitin and TDP-43 positive aggregates which are likely related to specific gene expression profiles. We carried out gene expression microarray analysis on post-mortem brain tissue from FTLD-U, FTLD-MND, and controls. Using total RNA from carefully dissected frontal cortical layer II, we obtained gene expression profiles showing that FTLD-U and controls differ in over 100 networks, including those involved in synapse formation, the ubiquitin-proteasome system, endosomal sorting, and apoptosis. We performed qRT-PCR validation for three genes, representative of three different networks. Dynein axonemal light intermediate chain 1 (DNALI1) (microtubule/cytoskeleton network associated) expression was 3-fold higher and myeloid differentiation primary response gene 88 (MYD88) (signal transduction network) was 3.3 times higher in FTLD-U than FTLD-MND and controls; annexin A2 (ANXA2) (endosomal sorting) expression was 11.3-fold higher in FTLD-U than FTLD-MND and 2.3-fold higher than controls. The identification of progranulin (PGRN) gene mutations and TDP-43 as the major protein component of the ubiquitinated inclusions, are two recent landmark discoveries in the field of FTLD-U. We found 1.5-fold increase in TDP-43 in both FTLD-MND and FTLD-U while progranulin showed no gene expression differences between controls and FTLD-MND. However, one of the FTLD-U cases tested by Affymetrix microarray showed "absence call" of this transcript, suggesting absent or decreased gene expression. Our findings point to specific gene-linked-pathways which may be influenced by neurodegenerative disease process and may be targeted for further exploration. | lld:pubmed |
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| pubmed-article:17569064 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17569064 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17569064 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17569064 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17569064 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17569064 | pubmed:issn | 0001-6322 | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:WoloschakGayl... | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:PauneskuTatja... | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:SiddiqueTeepu... | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:BigioEileen... | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:LinSimonS | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:MishraManjari... | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:ZhuLihua... | lld:pubmed |
| pubmed-article:17569064 | pubmed:author | pubmed-author:GrecoKristinK | lld:pubmed |
| pubmed-article:17569064 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17569064 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:17569064 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17569064 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17569064 | pubmed:pagination | 81-94 | lld:pubmed |
| pubmed-article:17569064 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17569064 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17569064 | pubmed:articleTitle | Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions. | lld:pubmed |
| pubmed-article:17569064 | pubmed:affiliation | Cognitive Neurology and Alzheimer Disease Center, Northwestern University, Feinberg School of Medicine, 320 East Superior St, Chicago, IL, 60611, USA. manjari@northwestern.edu | lld:pubmed |
| pubmed-article:17569064 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17569064 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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