| pubmed-article:1756860 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C0002520 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C0061928 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C0242853 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C1419277 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C1149036 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:1756860 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:1756860 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1756860 | pubmed:dateCreated | 1992-2-5 | lld:pubmed |
| pubmed-article:1756860 | pubmed:abstractText | To determine the amino acid residues required for the signal-transducing activity of the human c-Ha-Ras protein, we introduced point mutations at residues 45-54 near the 'effector region' (residues 32-40). We transfected PC12 cells with these mutant genes and also micro-injected the mutant proteins, bound with an unhydrolyzable GTP analog, into PC12 cells. Both procedures showed that Val45----Glu and Gly48----Cys mutations impaired the ability of the Ras protein to induce morphological change of PC12 cells. These mutations did not affect the guanine nucleotide-binding activity or GTPase activity in the absence or presence of bovine GTPase-activating protein (GAP). Therefore, the Val45 and Gly48 residues should be included by definition in the effector region responsible for the signal transduction, while only a subset of the effector-region residues is required for enhancement of the GTPase activity by GAP. | lld:pubmed |
| pubmed-article:1756860 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1756860 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1756860 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1756860 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1756860 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:1756860 | pubmed:author | pubmed-author:KoideHH | lld:pubmed |
| pubmed-article:1756860 | pubmed:author | pubmed-author:NishimuraSS | lld:pubmed |
| pubmed-article:1756860 | pubmed:author | pubmed-author:YokoyamaSS | lld:pubmed |
| pubmed-article:1756860 | pubmed:author | pubmed-author:Fujita-Yoshig... | lld:pubmed |
| pubmed-article:1756860 | pubmed:author | pubmed-author:ShirouzuMM | lld:pubmed |
| pubmed-article:1756860 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1756860 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:1756860 | pubmed:volume | 294 | lld:pubmed |
| pubmed-article:1756860 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1756860 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1756860 | pubmed:pagination | 187-90 | lld:pubmed |
| pubmed-article:1756860 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:meshHeading | pubmed-meshheading:1756860-... | lld:pubmed |
| pubmed-article:1756860 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1756860 | pubmed:articleTitle | Identification of amino acid residues of Ras protein that are essential for signal-transducing activity but not for enhancement of GTPase activity by GAP. | lld:pubmed |
| pubmed-article:1756860 | pubmed:affiliation | Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:1756860 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1756860 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5921 | entrezgene:pubmed | pubmed-article:1756860 | lld:entrezgene |
