| pubmed-article:17561991 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17561991 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:17561991 | lifeskim:mentions | umls-concept:C0242957 | lld:lifeskim |
| pubmed-article:17561991 | lifeskim:mentions | umls-concept:C0348026 | lld:lifeskim |
| pubmed-article:17561991 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17561991 | pubmed:dateCreated | 2007-7-30 | lld:pubmed |
| pubmed-article:17561991 | pubmed:abstractText | HER-2/neu status of the primary breast cancer (PBC) is determined by immunohistochemistry and fluorescent in situ hybridization. Because of a variety of technical factors, however, the PBC may not accurately reflect the metastatic tumor in terms of HER-2/neu status. Recently published guidelines recommend that tumors be defined as HER-2/neu positive if 30% or more of the cells are 3+. Circulating levels of the HER-2 extracellular domain can be measured in serum using a test cleared by the US Food and Drug Administration, and increased serum HER-2/neu levels to above 15 ng/ml can reflect tumor progression. Studies comparing tissue HER-2/neu status of the PBC and HER-2/neu levels above 15 ng/ml in metastatic breast cancer patients are also reviewed. | lld:pubmed |
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| pubmed-article:17561991 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17561991 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17561991 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17561991 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17561991 | pubmed:issn | 1465-542X | lld:pubmed |
| pubmed-article:17561991 | pubmed:author | pubmed-author:LiptonAllanA | lld:pubmed |
| pubmed-article:17561991 | pubmed:author | pubmed-author:NeumannRainer... | lld:pubmed |
| pubmed-article:17561991 | pubmed:author | pubmed-author:LeitzelKimK | lld:pubmed |
| pubmed-article:17561991 | pubmed:author | pubmed-author:CarneyWalter... | lld:pubmed |
| pubmed-article:17561991 | pubmed:author | pubmed-author:AliSuhailS | lld:pubmed |
| pubmed-article:17561991 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17561991 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:17561991 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17561991 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17561991 | pubmed:pagination | 207 | lld:pubmed |
| pubmed-article:17561991 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17561991 | pubmed:meshHeading | pubmed-meshheading:17561991... | lld:pubmed |
| pubmed-article:17561991 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17561991 | pubmed:articleTitle | HER-2/neu diagnostics in breast cancer. | lld:pubmed |
| pubmed-article:17561991 | pubmed:affiliation | Oncogene Science, Siemens Medical Solutions Diagnostics, Rogers Street, Cambridge, Massachusetts 02142, USA. walter.carney@siemens.com | lld:pubmed |
| pubmed-article:17561991 | pubmed:publicationType | Journal Article | lld:pubmed |
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