pubmed-article:17561988 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0036980 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0497247 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C1548568 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C1637379 | lld:lifeskim |
pubmed-article:17561988 | lifeskim:mentions | umls-concept:C0442739 | lld:lifeskim |
pubmed-article:17561988 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:17561988 | pubmed:dateCreated | 2008-1-16 | lld:pubmed |
pubmed-article:17561988 | pubmed:abstractText | The TRIUMPH study, recently published in Journal of the American Medical Association, was a prospective randomized placebo-controlled trial testing the hypothesis that tilarginine (a non-specific inhibitor of nitric oxide synthase), when compared with placebo, would reduce 30-day mortality by 25% in patients with myocardial infarction complicated by refractory cardiogenic shock despite successful revascularization of the infarct-related artery. Patients received an intravenous bolus of the drug followed by 5 hours of intravenous infusion of the drug or a matching placebo. Although tilarginine increased systolic blood pressure by 5 mmHg at 2 hours, no effect on mortality was observed at 30 days. There was, however, a 6% absolute increase in 30-day mortality in the tilarginine group (48%, versus 42% in the placebo). This definitive trial gave strong indications for stopping any further trial using non-specific inhibitors of nitric oxide synthase in cardiogenic shock and possibly also in any other cardiovascular area. | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:language | eng | lld:pubmed |
pubmed-article:17561988 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17561988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17561988 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17561988 | pubmed:issn | 1466-609X | lld:pubmed |
pubmed-article:17561988 | pubmed:author | pubmed-author:MebazaaAlexan... | lld:pubmed |
pubmed-article:17561988 | pubmed:author | pubmed-author:SalemRédaR | lld:pubmed |
pubmed-article:17561988 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:17561988 | pubmed:volume | 11 | lld:pubmed |
pubmed-article:17561988 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17561988 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17561988 | pubmed:pagination | 136 | lld:pubmed |
pubmed-article:17561988 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:meshHeading | pubmed-meshheading:17561988... | lld:pubmed |
pubmed-article:17561988 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17561988 | pubmed:articleTitle | Nitric oxide inhibition rapidly increases blood pressure with no change in outcome in cardiogenic shock: the TRIUMPH trial. | lld:pubmed |
pubmed-article:17561988 | pubmed:affiliation | Département de Cardiologie, Centre Hospitalier de l'université de Montréal, 3840 rue Saint-Urbain Montréal (Québec)H2W 1T8, Canada. | lld:pubmed |
pubmed-article:17561988 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17561988 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |