| pubmed-article:17560787 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C0017924 | lld:lifeskim |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C1412167 | lld:lifeskim |
| pubmed-article:17560787 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:17560787 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17560787 | pubmed:dateCreated | 2007-7-13 | lld:pubmed |
| pubmed-article:17560787 | pubmed:abstractText | We assessed the possible association existing between alpha-actinin-3 (ACTN3) R577X genotypes and the capacity for performing aerobic exercise in McArdle's patients. Forty adult McArdle's disease patients and forty healthy, age and gender-matched sedentary controls (21 men, 19 women in both groups) performed a graded test until exhaustion and a constant-load test on a cycle-ergometer to determine clinically relevant indices of exercise capacity as peak oxygen uptake (VO(2peak)) and the ventilatory threshold (VT). In the group of diseased women, carriers of the X allele had a higher (P<0.01) VO(2peak) (15.0+/-1.2 ml/kg/min) and a higher (P<0.05) oxygen uptake (VO(2)) at the VT (11.2+/-1 ml/kg/min) than R/R homozygotes (VO(2peak): 9.6+/-0.5 ml/kg/min; VO(2) at the VT: 8.2+/-0.7 ml/kg/min). No differences were found in male patients. In women with McArdle's disease, ACTN3 genotypes might partly explain the large individual variability that exists in the phenotypic manifestation of this disorder. | lld:pubmed |
| pubmed-article:17560787 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17560787 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17560787 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17560787 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17560787 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17560787 | pubmed:issn | 0960-8966 | lld:pubmed |
| pubmed-article:17560787 | pubmed:author | pubmed-author:ArenasJoaquín... | lld:pubmed |
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| pubmed-article:17560787 | pubmed:author | pubmed-author:PérezMargarit... | lld:pubmed |
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| pubmed-article:17560787 | pubmed:author | pubmed-author:LuciaAlejandr... | lld:pubmed |
| pubmed-article:17560787 | pubmed:author | pubmed-author:RubioJuan CJC | lld:pubmed |
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| pubmed-article:17560787 | pubmed:author | pubmed-author:Maté-MuñozJos... | lld:pubmed |
| pubmed-article:17560787 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17560787 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17560787 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17560787 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17560787 | pubmed:pagination | 603-10 | lld:pubmed |
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| pubmed-article:17560787 | pubmed:meshHeading | pubmed-meshheading:17560787... | lld:pubmed |
| pubmed-article:17560787 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17560787 | pubmed:articleTitle | The 577X allele of the ACTN3 gene is associated with improved exercise capacity in women with McArdle's disease. | lld:pubmed |
| pubmed-article:17560787 | pubmed:affiliation | Universidad Europea de Madrid, Madrid, Spain. alejandro.lucia@uem.es | lld:pubmed |
| pubmed-article:17560787 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17560787 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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