| pubmed-article:17555831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C1458155 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C2350332 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C1840264 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C0010467 | lld:lifeskim |
| pubmed-article:17555831 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:17555831 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17555831 | pubmed:dateCreated | 2007-6-18 | lld:pubmed |
| pubmed-article:17555831 | pubmed:abstractText | An important characteristic of tumors is that they at some point in their development overcome the surveillance of the immune system. Tumors secrete exosomes, multivesicular bodies containing a distinct set of proteins that can fuse with cells of the circulating immune system. Purified exosomes from TS/A breast cancer cells, but not non-exosomal fractions, inhibit (at concentrations of nanograms per ml protein) IL-2-induced natural killer (NK) cell cytotoxicity. The dietary polyphenol, curcumin (diferuloylmethane), partially reverses tumor exosome-mediated inhibition of natural killer cell activation, which is mediated through the impairment of the ubiquitin-proteasome system. Exposure of mouse breast tumor cells to curcumin causes a dose-dependent increase in ubiquitinated exosomal proteins compared to those in untreated TS/A breast tumor cells. Furthermore, exosomes isolated from tumor cells pretreated with curcumin have a much attenuated inhibition of IL-2 stimulated NK cell activation. Jak3-mediated activation of Stat5 is required for tumor cytotoxicity of IL-2 stimulated NK cells. TS/A tumor exosomes strongly inhibit activation of Stat5, whereas the tumor exosomes isolated from curcumin-pretreated tumor cells have a lowered potency for inhibition of IL-2 stimulated NK cell cytotoxicity. These data suggest that partial reversal of tumor exosome-mediated inhibition of NK cell tumor cytotoxicity may account for the anti-cancer properties of curcumin. | lld:pubmed |
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| pubmed-article:17555831 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17555831 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17555831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17555831 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17555831 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:HilesA MAM | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:BarnesStephen... | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:WangJianhuaJ | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:GrizzleWillia... | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:ZhangHuang-Ge... | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:KimberlyRober... | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:LiuCunrenC | lld:pubmed |
| pubmed-article:17555831 | pubmed:author | pubmed-author:YuShaohuaS | lld:pubmed |
| pubmed-article:17555831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17555831 | pubmed:volume | 1773 | lld:pubmed |
| pubmed-article:17555831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17555831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17555831 | pubmed:pagination | 1116-23 | lld:pubmed |
| pubmed-article:17555831 | pubmed:dateRevised | 2011-4-25 | lld:pubmed |
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