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pubmed-article:17553289pubmed:abstractTextTo investigate the exact isolation frequency of 16S rRNA methylase-producing, gram-negative pathogenic bacteria, we tested 87,626 clinical isolates from 169 hospitals. Twenty-six strains from 16 hospitals harbored 16S rRNA methylase genes, which suggests sparse but diffuse spread of pan-aminoglycoside-resistant microbes in Japan.lld:pubmed
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pubmed-article:17553289pubmed:affiliationNational Institute of Infectious Diseases, Tokyo, Japan.lld:pubmed
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