| pubmed-article:1754104 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1754104 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1754104 | lifeskim:mentions | umls-concept:C0002351 | lld:lifeskim |
| pubmed-article:1754104 | lifeskim:mentions | umls-concept:C0103647 | lld:lifeskim |
| pubmed-article:1754104 | lifeskim:mentions | umls-concept:C0264939 | lld:lifeskim |
| pubmed-article:1754104 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1754104 | lifeskim:mentions | umls-concept:C1517942 | lld:lifeskim |
| pubmed-article:1754104 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1754104 | pubmed:dateCreated | 1992-1-28 | lld:pubmed |
| pubmed-article:1754104 | pubmed:abstractText | Anti-neutrophil cytoplasmic antibodies (ANCA) have been identified as a diagnostic marker in primary systemic vasculitis, and immunofluorescence assays identify two patterns of binding: cytoplasmic (C-ANCA and perinuclear (P-ANCA). We have examined retrospectively the use of such assays in long-term monitoring of disease activity, in order to determine the relationship between presence of ANCA and relapse, and to assess their suitability as a guide to therapy. Seventy patients were studied over a period of 50 months, using clinical and laboratory criteria for the diagnosis of relapse and the internationally standardised immunofluorescence assay for detection of ANCA. In 19 patients C- or P-ANCA were detectable throughout the study period; six of these (with C-ANCA) relapsed. In 18 patients ANCA were undetectable during long-term follow-up; none of these patients relapsed. In 33 patients C- or P-ANCA were intermittently present; nine of these relapsed and all had C-ANCA detectable at the time of relapse. In six of the nine cases, relapse was accompanied or closely preceded by reappearance of C-ANCA. We conclude that continuing presence and reappearance of ANCA may identify patients who are at risk of relapse and who are most likely to benefit from long-term immunosuppressive therapy. | lld:pubmed |
| pubmed-article:1754104 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1754104 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1754104 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1754104 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1754104 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1754104 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1754104 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1754104 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1754104 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1754104 | pubmed:issn | 0931-0509 | lld:pubmed |
| pubmed-article:1754104 | pubmed:author | pubmed-author:JonesSS | lld:pubmed |
| pubmed-article:1754104 | pubmed:author | pubmed-author:RyanJ JJJ | lld:pubmed |
| pubmed-article:1754104 | pubmed:author | pubmed-author:LockwoodC MCM | lld:pubmed |
| pubmed-article:1754104 | pubmed:author | pubmed-author:ReesA JAJ | lld:pubmed |
| pubmed-article:1754104 | pubmed:author | pubmed-author:PuseyC DCD | lld:pubmed |
| pubmed-article:1754104 | pubmed:author | pubmed-author:GaskinGG | lld:pubmed |
| pubmed-article:1754104 | pubmed:author | pubmed-author:SavageC OCO | lld:pubmed |
| pubmed-article:1754104 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1754104 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1754104 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1754104 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1754104 | pubmed:pagination | 689-94 | lld:pubmed |
| pubmed-article:1754104 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:meshHeading | pubmed-meshheading:1754104-... | lld:pubmed |
| pubmed-article:1754104 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1754104 | pubmed:articleTitle | Anti-neutrophil cytoplasmic antibodies and disease activity during long-term follow-up of 70 patients with systemic vasculitis. | lld:pubmed |
| pubmed-article:1754104 | pubmed:affiliation | Department of Medicine, Royal Postgraduate Medical School, London, UK. | lld:pubmed |
| pubmed-article:1754104 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1754104 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1754104 | lld:pubmed |
