| pubmed-article:17532039 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17532039 | lifeskim:mentions | umls-concept:C0027836 | lld:lifeskim |
| pubmed-article:17532039 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17532039 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:17532039 | lifeskim:mentions | umls-concept:C0106006 | lld:lifeskim |
| pubmed-article:17532039 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:17532039 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:17532039 | pubmed:dateCreated | 2007-6-8 | lld:pubmed |
| pubmed-article:17532039 | pubmed:abstractText | Sodium salts of D-3-hydroxybutyrate (D-3-HB), DL-3-hydroxybutyrate (DL-3-HB) and methyl (D)-3-hydroxybutyrate (M-3-HB), are derivatives of 3-hydroxybutyric acid (3-HB), a ketone body that is produced in vivo in animals including human. D-3-HB is the most common degradation product of microbial polyhydroxyalkanoates (PHA) that have been investigated for tissue engineering application. This study evaluated the in vitro effect of PHA degradation product 3-HB and its derivatives (collectively called 3-HB derivatives) on cell apoptosis and cytosolic Ca(2+) concentration of mouse glial cells. Results showed that the percentage of cells undergoing apoptosis decreased significantly in the presence of 3-HB and its derivatives as evidenced by flow cytometry. The in vitro study on cytosolic Ca(2+) concentration demonstrated that 3-HB derivatives dramatically elevated the cytosolic Ca(2+) concentration. Both the extracellular and intracellular Ca(2+) contributed as the sources of such Ca(2+) concentration elevation. The effect of 3-HB derivatives on cytosolic Ca(2+) concentration could be reduced by nitredipine, an L-type voltage-dependent calcium channel antagonist. In comparison, M-3-HB worked more efficiently than D-3-HB and DL-3-HB did as M-3-HB is more efficient in permeation into the cells. All results indicated that 3-HB derivatives had an inhibitory effect on cell apoptosis which is mediated by signaling pathways related to the elevation of cytosolic Ca(2+) concentration. This positive effect helps explain the biocompatibility observed for PHA, it also points to the possibility of 3-HB derivatives regardless of chirality to become an effective neural protective agent. | lld:pubmed |
| pubmed-article:17532039 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17532039 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17532039 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17532039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17532039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17532039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17532039 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17532039 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17532039 | pubmed:issn | 0142-9612 | lld:pubmed |
| pubmed-article:17532039 | pubmed:author | pubmed-author:ChenGuo-Qiang... | lld:pubmed |
| pubmed-article:17532039 | pubmed:author | pubmed-author:ZhaoYanY | lld:pubmed |
| pubmed-article:17532039 | pubmed:author | pubmed-author:XiaoXiao-Qian... | lld:pubmed |
| pubmed-article:17532039 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17532039 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:17532039 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17532039 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17532039 | pubmed:pagination | 3608-16 | lld:pubmed |
| pubmed-article:17532039 | pubmed:meshHeading | pubmed-meshheading:17532039... | lld:pubmed |
| pubmed-article:17532039 | pubmed:meshHeading | pubmed-meshheading:17532039... | lld:pubmed |
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| pubmed-article:17532039 | pubmed:meshHeading | pubmed-meshheading:17532039... | lld:pubmed |
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| pubmed-article:17532039 | pubmed:meshHeading | pubmed-meshheading:17532039... | lld:pubmed |
| pubmed-article:17532039 | pubmed:meshHeading | pubmed-meshheading:17532039... | lld:pubmed |
| pubmed-article:17532039 | pubmed:meshHeading | pubmed-meshheading:17532039... | lld:pubmed |
| pubmed-article:17532039 | pubmed:meshHeading | pubmed-meshheading:17532039... | lld:pubmed |
| pubmed-article:17532039 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17532039 | pubmed:articleTitle | The effect of 3-hydroxybutyrate and its derivatives on the growth of glial cells. | lld:pubmed |
| pubmed-article:17532039 | pubmed:affiliation | Multidisciplinary Research Center, Shantou University, Shantou 515063, Guangdong, China. | lld:pubmed |
| pubmed-article:17532039 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17532039 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17532039 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17532039 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17532039 | lld:pubmed |
