Source:http://linkedlifedata.com/resource/pubmed/id/17521206
| Subject | Predicate | Object | Context |
|---|---|---|---|
| pubmed-article:17521206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17521206 | lifeskim:mentions | umls-concept:C0056784 | lld:lifeskim |
| pubmed-article:17521206 | lifeskim:mentions | umls-concept:C1718271 | lld:lifeskim |
| pubmed-article:17521206 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:17521206 | pubmed:dateCreated | 2007-6-12 | lld:pubmed |
| pubmed-article:17521206 | pubmed:abstractText | Monolayers of di-6A,6B-deoxy-6-(4-pyridylmethyl)amino-gamma-cyclodextrin (gamma-CD-(py)2) have been formed on polycrystalline platinum electrodes and investigated using electrochemical and surface-enhanced Raman spectroscopy (SERS). The behavior of self-assembled monolayers of (gamma-CD-(py)2) alone, (gamma-CD-(py)2) backfilled with 1-nonanethiol, and 1-nonanethiol are reported. The potential dependence of the capacitance indicates that the film capacitance is higher for the backfilled CD layers than for 1-nonanethiol layers, most likely due to ion flux through the CD cavity. SERS spectra of the backfilled layer exhibit features associated with both pyridine-functionalized CD and alkane moieties. Investigations using [Fe(CN)6]4- as a solution-phase probe indicate that the backfilled CD-alkane thiol layer exhibits enhanced blocking properties compared to gamma-CD-(py)2 films alone. Complete blocking was achieved by a combination of backfilling and insertion of a high-affinity guest 1-adamantylamine into the cavity. Significantly, an electroactive guest with high affinity for gamma-CD, [Co(biptpy)2]2+, does not exhibit a redox response at the gamma-CD-(py)2 layer but molecular recognition is turned on by backfilling the CD layer with 1-nonanethiol molecules. This switching on of the electrochemical activity suggests that the CD hosts are initially inaccessible but reorientate upon backfilling, exposing the CD opening to solution and permitting a supramolecular host-guest complex to form. The binding of [Co(biptpy)2]2+ to gamma-CD in the backfilled monolayer depends on the bulk concentration of guest and is modeled by the Langmuir isotherm, yielding an association constant for the Co2+ state of 1.45 +/- 0.46 x 105 M-1 and a limiting surface coverage 1.49 +/- 0.25 x 10-11 mol cm-2. The surface coverage of the divalent state is higher than the trivalent state, reflecting the dynamic nature of the inclusion. | lld:pubmed |
| pubmed-article:17521206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17521206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17521206 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:17521206 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17521206 | pubmed:issn | 0743-7463 | lld:pubmed |
| pubmed-article:17521206 | pubmed:author | pubmed-author:ForsterRobert... | lld:pubmed |
| pubmed-article:17521206 | pubmed:author | pubmed-author:KeyesTia ETE | lld:pubmed |
| pubmed-article:17521206 | pubmed:author | pubmed-author:PikramenouZoe... | lld:pubmed |
| pubmed-article:17521206 | pubmed:author | pubmed-author:McNallyAndrea... | lld:pubmed |
| pubmed-article:17521206 | pubmed:author | pubmed-author:MallonColm... | lld:pubmed |
| pubmed-article:17521206 | pubmed:author | pubmed-author:CampagnoliEle... | lld:pubmed |
| pubmed-article:17521206 | pubmed:issnType | lld:pubmed | |
| pubmed-article:17521206 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:17521206 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:17521206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17521206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17521206 | pubmed:pagination | 6997-7002 | lld:pubmed |
| pubmed-article:17521206 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17521206 | pubmed:articleTitle | Surface-immobilized pyridine-functionalized gamma-cyclodextrin: alkanethiol co-adsorption-induced reorientation. | lld:pubmed |
| pubmed-article:17521206 | pubmed:affiliation | National Center for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. | lld:pubmed |
| pubmed-article:17521206 | pubmed:publicationType | Journal Article | lld:pubmed |