| pubmed-article:17510063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C1335828 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C1424951 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17510063 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:17510063 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:17510063 | pubmed:dateCreated | 2007-7-9 | lld:pubmed |
| pubmed-article:17510063 | pubmed:abstractText | Transforming growth factor-beta (TGF-beta) signaling is controlled by a variety of regulators that target either signaling receptors or activated Smad complexes. Among the negative regulators, Smad7 antagonizes TGF-beta signaling mainly through targeting the signaling receptors, whereas SnoN and c-Ski repress signaling at the transcriptional level through inactivation of Smad complexes. We previously found that Arkadia is a positive regulator of TGF-beta signaling that induces ubiquitin-dependent degradation of Smad7 through its C-terminal RING domain. We report here that Arkadia induces degradation of SnoN and c-Ski in addition to Smad7. Arkadia interacts with SnoN and c-Ski in their free forms as well as in the forms bound to Smad proteins, and constitutively down-regulates levels of their expression. Arkadia thus appears to effectively enhance TGF-beta signaling through simultaneous down-regulation of two distinct types of negative regulators, Smad7 and SnoN/c-Ski, and may play an important role in determining the intensity of TGF-beta family signaling in target cells. | lld:pubmed |
| pubmed-article:17510063 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17510063 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17510063 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17510063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17510063 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17510063 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:MiyazonoKohei... | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:MiyazawaKeiji... | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:KoinumaDaizoD | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:ImamuraTakesh... | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:SaitohMasaoM | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:FujiiTomokoT | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:MavrakisKonst... | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:EpiskopouVass... | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:LeeKian... | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:NaganoYoshiko... | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:SaseHitoshiH | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:YukiKeikoK | lld:pubmed |
| pubmed-article:17510063 | pubmed:author | pubmed-author:IsogayaKazuno... | lld:pubmed |
| pubmed-article:17510063 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17510063 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:17510063 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:17510063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17510063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17510063 | pubmed:pagination | 20492-501 | lld:pubmed |
| pubmed-article:17510063 | pubmed:dateRevised | 2011-10-24 | lld:pubmed |
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| pubmed-article:17510063 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17510063 | pubmed:articleTitle | Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. | lld:pubmed |
| pubmed-article:17510063 | pubmed:affiliation | Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. | lld:pubmed |
| pubmed-article:17510063 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17510063 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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