| pubmed-article:17509016 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0038351 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0013303 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0682132 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C1420214 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17509016 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17509016 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17509016 | pubmed:dateCreated | 2007-5-18 | lld:pubmed |
| pubmed-article:17509016 | pubmed:abstractText | The aim of this study was to increase the understanding of the role of serotonergic signalling in normal gastroduodenal function at a molecular level. Mucosal biopsy specimens were collected from the fundus, antrum and duodenum of 11 healthy subjects. Serotonin (5-HT)-positive cells were counted and the mRNA levels of tryptophan hydroxylase (TPH), serotonin transporter (SERT), 5-HT(4) receptor and 5-HT(3) receptor subunits were quantified by real-time reverse transcription polymerase chain reaction. The number of 5-HT-positive cells was larger in the duodenum compared with the stomach (P < 0.001). Serotonin transport protein expression was 19-fold higher in the duodenum compared with the antrum and 457-fold higher compared with the fundus (P < 0.001). Tryptophan hydroxylase-1 expression was lower in the duodenum compared with the antrum and fundus (regional differences -2.3 and -3.6, respectively). The 5-HT(4) receptor and the 5-HT(3C) and 5-HT(3E) receptor subunits were more abundantly expressed in duodenum compared with the stomach (P < 0.001). The larger number of 5-HT-positive cells, the higher expression of 5-HT(3) and 5-HT(4) receptors, and in particularly the higher uptake capacity of 5-HT in the duodenum, point out to a more prominent role of serotonergic signalling at the mucosal level in the duodenum compared with the stomach. | lld:pubmed |
| pubmed-article:17509016 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17509016 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17509016 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17509016 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17509016 | pubmed:month | May | lld:pubmed |
| pubmed-article:17509016 | pubmed:issn | 1350-1925 | lld:pubmed |
| pubmed-article:17509016 | pubmed:author | pubmed-author:SamsonLL | lld:pubmed |
| pubmed-article:17509016 | pubmed:author | pubmed-author:Ter LindeJJ | lld:pubmed |
| pubmed-article:17509016 | pubmed:author | pubmed-author:SchipperM E... | lld:pubmed |
| pubmed-article:17509016 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:17509016 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17509016 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:17509016 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17509016 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17509016 | pubmed:pagination | 342-8 | lld:pubmed |
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| pubmed-article:17509016 | pubmed:meshHeading | pubmed-meshheading:17509016... | lld:pubmed |
| pubmed-article:17509016 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17509016 | pubmed:articleTitle | Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum. | lld:pubmed |
| pubmed-article:17509016 | pubmed:affiliation | Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands. n.vanlelyveld@azu.nl | lld:pubmed |
| pubmed-article:17509016 | pubmed:publicationType | Journal Article | lld:pubmed |
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