| pubmed-article:175084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:175084 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:175084 | lifeskim:mentions | umls-concept:C0005261 | lld:lifeskim |
| pubmed-article:175084 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:175084 | lifeskim:mentions | umls-concept:C0574895 | lld:lifeskim |
| pubmed-article:175084 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:175084 | lifeskim:mentions | umls-concept:C0456389 | lld:lifeskim |
| pubmed-article:175084 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:175084 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:175084 | pubmed:dateCreated | 1976-4-23 | lld:pubmed |
| pubmed-article:175084 | pubmed:abstractText | Gel chromatographic, immunologic and biologic properties of beta-melanocyte-stimulating hormone (beta-MSH) in tumor tissues obtained from eight patients with the ectopic ACTH syndrome were studied and compared to those of pituitary beta-MSH. Size heterogeneity of immunoreactive beta-MSH was found in all the tumors studied as well as in normal human pituitaries. Both the tumors and pituitaries contained immunoreactive beta-MSH of a larger molecular size than the well-characterized beta-MSH of small molecular size. The large molecular weight beta-MSH also predominated in the plasma. It was found to be bioactive by an in vitro MSH assay, immunologically indistinguishable from human beta-MSH, and chromatographically very similar to beta-lipotropic hormone (beta-LPH). Tryptic digestion of the large molecular weight beta-MSH under controlled conditions promptly produced bioactive beta-MSH of small molecular size, followed by the appearance of immunologically active but biologically inert fragments. These results suggest that the ectopic ACTH-producing tumor as well as the pituitary elaborate beta-LPH-like peptide which might be the predominant component of immunoreactive beta-MSH in man. | lld:pubmed |
| pubmed-article:175084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:175084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:175084 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:175084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:175084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:175084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:175084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:175084 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:175084 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:175084 | pubmed:author | pubmed-author:TanakaAA | lld:pubmed |
| pubmed-article:175084 | pubmed:author | pubmed-author:HirataYY | lld:pubmed |
| pubmed-article:175084 | pubmed:author | pubmed-author:NakamuraMM | lld:pubmed |
| pubmed-article:175084 | pubmed:author | pubmed-author:ImuraHH | lld:pubmed |
| pubmed-article:175084 | pubmed:author | pubmed-author:MatsukuraSS | lld:pubmed |
| pubmed-article:175084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:175084 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:175084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:175084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:175084 | pubmed:pagination | 33-40 | lld:pubmed |
| pubmed-article:175084 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:175084 | pubmed:meshHeading | pubmed-meshheading:175084-H... | lld:pubmed |
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| pubmed-article:175084 | pubmed:meshHeading | pubmed-meshheading:175084-M... | lld:pubmed |
| pubmed-article:175084 | pubmed:meshHeading | pubmed-meshheading:175084-P... | lld:pubmed |
| pubmed-article:175084 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:175084 | pubmed:articleTitle | Size heterogeneity of beta-MSH in ectopic ACTH-producing tumors: presence of beta-LPH-like peptide. | lld:pubmed |
| pubmed-article:175084 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:175084 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:175084 | lld:pubmed |
