| pubmed-article:1750081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C0035015 | lld:lifeskim |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:1750081 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:1750081 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1750081 | pubmed:dateCreated | 1992-1-23 | lld:pubmed |
| pubmed-article:1750081 | pubmed:abstractText | The term combi-effect was introduced to describe the phenomenon of a reduction in rejection of heart grafts after combined transplantation with the lung. In this study in rats we investigated whether the combi-effect was an immunological process and whether it could also be induced by combined transplantation of the heart with the spleen or with a lymphocyte-depleted spleen. Heart and spleen grafts were transplanted into the abdomen; left lungs were transplanted into the thorax of recipient rats. To deplete spleens of their lymphocytes, prospective donor rats were irradiated. Cyclosporine was injected once, on day 2 after transplantation. All heart allografts transplanted alone and treated with cyclosporine were rejected acutely (median survival time [MST] of 14.5 days). In contrast, after combined transplantation of a donor lung or spleen with the heart, almost all heart grafts survived indefinitely. Transplantation of a syngeneic lung or third-party spleen had little effect on heart graft survival (MST of 22.5 days and 26.5 days, respectively). Without cyclosporine treatment, combined transplantation with a donor lung or spleen hardly prolonged heart graft survival. Transplantation of a lymphocyte-depleted spleen with the heart induced a combi-effect in cyclosporine-treated rats that was somewhat weaker: only two of six hearts survived indefinitely. We conclude that in the combi-effect an immunological mechanism reduces rejection of the heart. This mechanism is probably generated by the lymphoid tissue (bronchus-associated lymphoid tissue in lung and white pulp in spleen) in the combined transplant. | lld:pubmed |
| pubmed-article:1750081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1750081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1750081 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1750081 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1750081 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1750081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1750081 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1750081 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:1750081 | pubmed:author | pubmed-author:WildevuurC... | lld:pubmed |
| pubmed-article:1750081 | pubmed:author | pubmed-author:ProtNN | lld:pubmed |
| pubmed-article:1750081 | pubmed:author | pubmed-author:PetersenA HAH | lld:pubmed |
| pubmed-article:1750081 | pubmed:author | pubmed-author:WestraA LAL | lld:pubmed |
| pubmed-article:1750081 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1750081 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:1750081 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1750081 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1750081 | pubmed:pagination | 952-5 | lld:pubmed |
| pubmed-article:1750081 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:meshHeading | pubmed-meshheading:1750081-... | lld:pubmed |
| pubmed-article:1750081 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1750081 | pubmed:articleTitle | The combi-effect--reduced rejection of the heart by combined transplantation with the lung or spleen. | lld:pubmed |
| pubmed-article:1750081 | pubmed:affiliation | Cardiopulmonary Surgery Research Division, Thoraxcentrum, University Hospital Groningen, The Netherlands. | lld:pubmed |
| pubmed-article:1750081 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1750081 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1750081 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1750081 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1750081 | lld:pubmed |
