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pubmed-article:17488695pubmed:abstractTextPegylated liposomal doxorubicin (Peg-Doxo) is a promising drug for advanced/recalcitrant primary cutaneous T-cell lymphomas (CTCLs). This prospective phase II trial enrolled 19 patients. We observed overall and complete response rates of 84.2% and 42.1% (with no significant differences between stage I-IIA and IIB-IV patients), and 11% grade III/IV toxicity. After a maximum 46 month-follow-up, median overall (OS), event-free (EFS) and progression-free (PFS) survival were 34, 18 and 19 months. OS, EFS and PFS rates at 46 months were 44%, 30% and 37% respectively. Peg-Doxo seems to be an active and safe principle that should be used in plurirelapsed, early stage-MF and in combination with other chemotherapeutic agents in advanced and aggressive CTCLs.lld:pubmed
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pubmed-article:17488695pubmed:articleTitlePegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomas.lld:pubmed
pubmed-article:17488695pubmed:affiliationClinic of Hematology, Polytechnic University of the Marche, Medical School, Ospedali Riuniti Umberto I, G.M. Lancisi-G. Salesi, Ancona, Italy. stpulini@bigfoot.comlld:pubmed
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pubmed-article:17488695pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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