| pubmed-article:17484771 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0018154 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C1819426 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17484771 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17484771 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17484771 | pubmed:dateCreated | 2007-8-10 | lld:pubmed |
| pubmed-article:17484771 | pubmed:abstractText | Heterotrimeric G(i) proteins play a role in signalling activated by lipopolysaccharide (LPS), Staphylococcus aureus (SA) and group B streptococci (GBS), leading to production of inflammatory mediators. We hypothesized that genetic deletion of G(i) proteins would alter cytokine and chemokine production induced by LPS, SA and GBS stimulation. LPS-induced, heat-killed SA-induced and heat-killed GBS-induced cytokine and chemokine production in peritoneal macrophages from wild-type (WT), Galpha(i2) (-/-) or Galpha(i1/3) (-/-) mice were investigated. LPS induced production of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA induced TNF-alpha, and IL-1beta production; and GBS induced TNF-alpha, IL-6, IL-1beta, macrophage inflammatory protein-1alpha (MIP-1alpha) and keratinocyte chemoattract (KC) production were all decreased (P < 0.05) in Galpha(i2) (-/-) or Galpha(i1/3) (-/-) mice compared with WT mice. In contrast to the role of G(i) proteins as a positive regulator of mediators, LPS-induced production of MIP-1alpha and granulocyte-macrophage colony-stimulating factor (GM-CSF) were increased in macrophages from Galpha(i1/3) (-/-) mice, and SA-induced MIP-1alpha production was increased in both groups of Galpha(i) protein-depleted mice. LPS-induced production of KC and IL-1beta, SA-induced production of GM-CSF, KC and IP-10, and GBS-induced production of IL-10, GM-CSF and IP-10 were unchanged in macrophages from Galpha(i2) (-/-) or Galpha(i1/3) (-/-) mice compared with WT mice. These data suggest that G(i2) and G(i1/3) proteins are both involved and differentially regulate murine inflammatory cytokine and chemokine production in response to both LPS and Gram-positive microbial stimuli. | lld:pubmed |
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| pubmed-article:17484771 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17484771 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17484771 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17484771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17484771 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17484771 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17484771 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:BirnbaumerLut... | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:SpicherKarste... | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:BoulayGuylain... | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:WilliamsDavid... | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:ZingarelliBas... | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:HalushkaPerry... | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:TetiGiuseppeG | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:CookJames AJA | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:FanHongkuanH | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:TempelGeorge... | lld:pubmed |
| pubmed-article:17484771 | pubmed:author | pubmed-author:BreuelKevin... | lld:pubmed |
| pubmed-article:17484771 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17484771 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:17484771 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17484771 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17484771 | pubmed:pagination | 116-23 | lld:pubmed |
| pubmed-article:17484771 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17484771 | pubmed:meshHeading | pubmed-meshheading:17484771... | lld:pubmed |
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| pubmed-article:17484771 | pubmed:meshHeading | pubmed-meshheading:17484771... | lld:pubmed |
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| pubmed-article:17484771 | pubmed:meshHeading | pubmed-meshheading:17484771... | lld:pubmed |
| pubmed-article:17484771 | pubmed:meshHeading | pubmed-meshheading:17484771... | lld:pubmed |
| pubmed-article:17484771 | pubmed:meshHeading | pubmed-meshheading:17484771... | lld:pubmed |
| pubmed-article:17484771 | pubmed:meshHeading | pubmed-meshheading:17484771... | lld:pubmed |
| pubmed-article:17484771 | pubmed:meshHeading | pubmed-meshheading:17484771... | lld:pubmed |
| pubmed-article:17484771 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17484771 | pubmed:articleTitle | Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins. | lld:pubmed |
| pubmed-article:17484771 | pubmed:affiliation | Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA. | lld:pubmed |
| pubmed-article:17484771 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17484771 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
