| pubmed-article:1748286 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0242611 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C1823600 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0243127 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C1157567 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1748286 | lifeskim:mentions | umls-concept:C0443331 | lld:lifeskim |
| pubmed-article:1748286 | pubmed:issue | 12A | lld:pubmed |
| pubmed-article:1748286 | pubmed:dateCreated | 1992-1-21 | lld:pubmed |
| pubmed-article:1748286 | pubmed:abstractText | mRNA decay rates often increase when translation is terminated prematurely due to a frameshift or nonsense mutation. We have identified a yeast gene, UPF1, that codes for a trans-acting factor whose function is necessary for enhanced turnover of mRNAs containing a premature stop codon. In the absence of UPF1 function, frameshift or nonsense mutations in the HIS4 or LEU2 genes that normally cause rapid mRNA decay fail to have this effect. Instead, the mRNAs decay at rates similar to the corresponding wild-type mRNAs. The stabilization of frameshift or nonsense mRNAs observed in upf1- strains does not appear to result from enhanced readthrough of the termination signal. Loss of UPF1 function has no effect on the accumulation or stability of HIS4+ or LEU2+ mRNA, suggesting that the UPF1 product functions only in response to a premature termination signal. When we examined the accumulation and stability of other wild-type mRNAs in the presence or absence of UPF1, including MAT alpha 1, STE3, ACT1, PGK1, PAB1, and URA3 mRNAs, only the URA3 transcript was affected. On the basis of these and other results, the UPF1 product appears to participate in a previously uncharacterized pathway leading to the degradation of a limited class of yeast transcripts. | lld:pubmed |
| pubmed-article:1748286 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1748286 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1748286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1748286 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1748286 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1748286 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:1748286 | pubmed:author | pubmed-author:CulbertsonM... | lld:pubmed |
| pubmed-article:1748286 | pubmed:author | pubmed-author:JacobsonAA | lld:pubmed |
| pubmed-article:1748286 | pubmed:author | pubmed-author:PeltzS WSW | lld:pubmed |
| pubmed-article:1748286 | pubmed:author | pubmed-author:LeedsPP | lld:pubmed |
| pubmed-article:1748286 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1748286 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1748286 | pubmed:geneSymbol | UPF1 | lld:pubmed |
| pubmed-article:1748286 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1748286 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1748286 | pubmed:pagination | 2303-14 | lld:pubmed |
| pubmed-article:1748286 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:meshHeading | pubmed-meshheading:1748286-... | lld:pubmed |
| pubmed-article:1748286 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1748286 | pubmed:articleTitle | The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. | lld:pubmed |
| pubmed-article:1748286 | pubmed:affiliation | Laboratories of Genetics and Molecular Biology, University of Wisconsin, Madison 53706. | lld:pubmed |
| pubmed-article:1748286 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1748286 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1748286 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1748286 | lld:pubmed |
