| pubmed-article:17481584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17481584 | lifeskim:mentions | umls-concept:C0230840 | lld:lifeskim |
| pubmed-article:17481584 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:17481584 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:17481584 | lifeskim:mentions | umls-concept:C2262814 | lld:lifeskim |
| pubmed-article:17481584 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17481584 | pubmed:dateCreated | 2007-5-15 | lld:pubmed |
| pubmed-article:17481584 | pubmed:abstractText | To explore the potential function of the BK channel in the inner mitochondrial membrane under physiological and hypoxic conditions, we used on-mitoplast and whole-mitoplast patches. Single BK channels had a conductance of 276+/-9 pS under symmetrical K(+) solutions, were Ca(2+)- and voltage-dependent and were inhibited by 0.1 microM charybdotoxin. In response to hypoxia, BK increased open probability, shifted its reversal potential (9.3+/-2.4 mV) in the positive direction and did not change its conductance. We conclude that (1) the properties at rest of this mitoplast K(+) channel are similar to those of BK channels in the plasma membrane; (2) hypoxia induces an increase, rather than a decrease (as in the plasmalemma), in the open probability of this K(+) channel, leading to K(+) efflux from the mitochondrial matrix to the outside. We speculate that this increase in K(+) efflux from mitochondria into the cytosol is important during hypoxia in maintaining cytosolic K(+). | lld:pubmed |
| pubmed-article:17481584 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17481584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17481584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17481584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17481584 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17481584 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:RoyS HSH | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:HaddadGabriel... | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:ZhouDanD | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:YuChengC | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:SunXiaoluX | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:SiemenDetlefD | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:GuXiang QXQ | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:ParvezSuhelS | lld:pubmed |
| pubmed-article:17481584 | pubmed:author | pubmed-author:JonasElizabet... | lld:pubmed |
| pubmed-article:17481584 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17481584 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:17481584 | pubmed:volume | 358 | lld:pubmed |
| pubmed-article:17481584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17481584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17481584 | pubmed:pagination | 311-6 | lld:pubmed |
| pubmed-article:17481584 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:meshHeading | pubmed-meshheading:17481584... | lld:pubmed |
| pubmed-article:17481584 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17481584 | pubmed:articleTitle | Hypoxia increases BK channel activity in the inner mitochondrial membrane. | lld:pubmed |
| pubmed-article:17481584 | pubmed:affiliation | Department of Pediatrics (Section of Respiratory Medicine), University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0735, USA. | lld:pubmed |
| pubmed-article:17481584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17481584 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17481584 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17481584 | lld:pubmed |
