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pubmed-article:1747697pubmed:abstractTextAntinuclear antibodies (ANA), as detected by indirect immunofluorescence on HEp-2 cells, have been investigated in five spouses and 41 first-degree relatives of nine probands with polymyositis-dermatomyositis (PM-DM) and in 41 sex- and age-matched controls. ANA were detected in 12 out of the 41 first-degree relatives and in two controls (chi 2 = 6.97; P less than 0.01). HLA typing was done in four out of the nine families; in two of them only, ANA segregated with a haplotype. ANA positivity was not correlated either to sex or to age or to household contact. Our results show that ANA occur in a significant percentage of first-degree relatives of patients with PM-DM. The finding seems to be genetically conditioned.lld:pubmed
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pubmed-article:1747697pubmed:articleTitleAntinuclear antibodies in first-degree relatives of patients with polymyositis-dermatomyositis: analysis of the relationship with HLA haplotypes.lld:pubmed
pubmed-article:1747697pubmed:affiliationDepartment of Medicine, 1st Faculty of Medicine, University of Naples 'Federico II', Italy.lld:pubmed
pubmed-article:1747697pubmed:publicationTypeJournal Articlelld:pubmed