| pubmed-article:17470540 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C0038170 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C0017718 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C0205169 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C1853126 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:17470540 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:17470540 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17470540 | pubmed:dateCreated | 2007-6-20 | lld:pubmed |
| pubmed-article:17470540 | pubmed:abstractText | Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective activity compared with antibodies that bind to PNAG with only high levels (>70%) of acetate. PNAG is synthesized by four proteins encoded within the intercellular adhesin (ica) locus icaADBC. In Staphylococcus epidermidis, icaB encodes a deacetylase needed for the surface retention of PNAG and optimal biofilm formation. In this study, we confirmed that icaB plays a similar role in Staphylococcus aureus and found that an icaB mutant of S. aureus expressed significantly less surface-associated PNAG, was highly susceptible to antibody-independent opsonic killing that could not be enhanced with antibody raised against deacetylated PNAG (dPNAG), and had reduced survival capacity in a murine model of bacteremia. In contrast, an icaB-overexpressing strain produced primarily surface-associated PNAG, was more susceptible to opsonophagocytosis with antibody to dPNAG, and had increased survival in a murine bacteremia model. The highly acetylated secreted PNAG was more effective at blocking opsonic killing mediated by a human monoclonal antibody (mAb) to native PNAG than it was at blocking killing mediated by a human mAb to dPNAG, which by itself was a more effective opsonin. Retention of dPNAG on the surface of S. aureus is key to increased survival during bacteremia and also provides a molecular mechanism explaining the superior opsonic and protective activity of antibody to dPNAG. | lld:pubmed |
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| pubmed-article:17470540 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17470540 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17470540 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17470540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17470540 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17470540 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17470540 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:PierGerald... | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:AzeredoJoanaJ | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:GoldmannDonal... | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:Maira-LitránT... | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:JeffersonKimb... | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:PierDanielle... | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:CercaNunoN | lld:pubmed |
| pubmed-article:17470540 | pubmed:author | pubmed-author:Kelly-Quintos... | lld:pubmed |
| pubmed-article:17470540 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17470540 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:17470540 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17470540 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17470540 | pubmed:pagination | 3406-13 | lld:pubmed |
| pubmed-article:17470540 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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