| pubmed-article:17465679 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0005682 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C1522538 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17465679 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17465679 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17465679 | pubmed:dateCreated | 2007-4-30 | lld:pubmed |
| pubmed-article:17465679 | pubmed:abstractText | The vigorous cytokine response of immune cells to Gram-negative bacteria is primarily mediated by a recognition molecule, Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharide (LPS) and initiates a series of intracellular NF-kappaB-associated signaling events. Recently, bladder epithelial cells (BECs) were reported to express TLR4 and to evoke a vigorous cytokine response upon exposure to LPS. We examined intracellular signaling events in human BECs leading to the production of IL-6, a major urinary cytokine, following activation by Escherichia coli and isolated LPS. We observed that in addition to the classical NF-kappaB-associated pathway, TLR4 triggers a distinct and more rapid signaling response involving, sequentially, Ca(2+), adenylyl cyclase 3-generated cAMP, and a transcriptional factor, cAMP response element-binding protein. This capacity of BECs to mobilize secondary messengers and evoke a more rapid IL-6 response might be critical in their role as first responders to microbial challenge in the urinary tract. | lld:pubmed |
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| pubmed-article:17465679 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17465679 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17465679 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17465679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17465679 | pubmed:status | MEDLINE | lld:pubmed |
