Linked Life Data

17464179

Source:http://linkedlifedata.com/resource/pubmed/id/17464179

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pubmed-article:17464179pubmed:abstractTextWe investigated the co-stimulatory role of a cell-surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or CD3+CD28. We also noted concomitant enhancement of the earliest T-cell receptor (TCR) signaling events. In addition, co-ligation of CD99 and CD3 led to translocation of TCR complexes into the lipid raft, without concomitant migration of CD99 to the raft, and consequent enhancement of TCR zeta-mediated signal 1. These data demonstrate the unique properties of CD99 co-stimulation that distinguish this molecule from CD28 and other raft-resident co-stimulatory factors.lld:pubmed
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pubmed-article:17464179pubmed:authorpubmed-author:OhKwon IkKIlld:pubmed
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pubmed-article:17464179pubmed:articleTitleCD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR zeta.lld:pubmed
pubmed-article:17464179pubmed:affiliationDepartment of Pathology, Hallym University College of Medicine, Chuncheon 200-702, Korea.lld:pubmed
pubmed-article:17464179pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17464179pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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