| pubmed-article:17460069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0288472 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0017710 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C1420626 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0598958 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17460069 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:17460069 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:17460069 | pubmed:dateCreated | 2007-4-26 | lld:pubmed |
| pubmed-article:17460069 | pubmed:abstractText | The role of glucocorticoids in the regulation of apoptosis remains incongruous. Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/Cip1) at Thr 145. Exposure of neurons to the neurotoxin ethylcholine aziridinium (AF64A) results in activation of caspase-3 and a dramatic loss of p21(Waf1/Cip1) preceding apoptosis in neurons. These effects of AF64A are reversed by pretreatment with corticosterone. Corticosterone-mediated upregulation of p21(Waf1/Cip1) and neuroprotection are completely abolished by glucocorticoid and mineralocorticoid receptor antagonists as well as inhibitors of PI3- and Akt-kinase. Both germline and somatically induced p21(Waf1/Cip1) deficiency abrogate the neuroprotection by corticosterone, whereas overexpression of p21(Waf1/Cip1) suffices to protect neurons from apoptosis. We identify p21(Waf1/Cip1) as a novel antiapoptotic factor for postmitotic neurons and implicate p21(Waf1/Cip1) as the molecular target of neuroprotection by high-dose glucocorticoids. | lld:pubmed |
| pubmed-article:17460069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17460069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17460069 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17460069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17460069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17460069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17460069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17460069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17460069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17460069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17460069 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17460069 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:HarmsChristop... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:HörtnaglHeide... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:DirnaglUlrich... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:HauckLudgerL | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:RuscherKarste... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:MeiselAndreas... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:EndresMatthia... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:HarmsUlrikeU | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:KronenbergGol... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:SeidelKerstin... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:AnJunfengJ | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:HübnerDeniseD | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:AlbrechtKatha... | lld:pubmed |
| pubmed-article:17460069 | pubmed:author | pubmed-author:BaldingerTina... | lld:pubmed |
| pubmed-article:17460069 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17460069 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:17460069 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:17460069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17460069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17460069 | pubmed:pagination | 4562-71 | lld:pubmed |
| pubmed-article:17460069 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17460069 | pubmed:meshHeading | pubmed-meshheading:17460069... | lld:pubmed |
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| pubmed-article:17460069 | pubmed:meshHeading | pubmed-meshheading:17460069... | lld:pubmed |
| pubmed-article:17460069 | pubmed:meshHeading | pubmed-meshheading:17460069... | lld:pubmed |
| pubmed-article:17460069 | pubmed:meshHeading | pubmed-meshheading:17460069... | lld:pubmed |
| pubmed-article:17460069 | pubmed:meshHeading | pubmed-meshheading:17460069... | lld:pubmed |
| pubmed-article:17460069 | pubmed:meshHeading | pubmed-meshheading:17460069... | lld:pubmed |
| pubmed-article:17460069 | pubmed:meshHeading | pubmed-meshheading:17460069... | lld:pubmed |
| pubmed-article:17460069 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17460069 | pubmed:articleTitle | Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids. | lld:pubmed |
| pubmed-article:17460069 | pubmed:affiliation | Klinik und Poliklinik für Neurologie, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, D-10117 Berlin, Germany. | lld:pubmed |
| pubmed-article:17460069 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17460069 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12575 | entrezgene:pubmed | pubmed-article:17460069 | lld:entrezgene |
| entrez-gene:114851 | entrezgene:pubmed | pubmed-article:17460069 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17460069 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17460069 | lld:entrezgene |
