| pubmed-article:17451636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C0030346 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C0036764 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:17451636 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:17451636 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17451636 | pubmed:dateCreated | 2007-5-8 | lld:pubmed |
| pubmed-article:17451636 | pubmed:abstractText | The serpin endopin 2A inhibits the cysteine protease papain in cross-class inhibition. This study demonstrates the novel finding that both the non-RSL NH(2)-domain and the RSL domain with P1-P1' residues participate in endopin 2A inhibition. Production of a chimeric mutant of endopin 2A with replacement of its NH(2)-domain with that of endopin 1 resulted in less effective inhibition of papain, indicated by its lower k(ass) association rate constant compared to wild-type endopin 2A. This chimeric mutant formed complexes with papain, but at lower levels compared to that with wild-type endopin 2A. Papain degradation of a portion of the chimeric mutant suggested a role for the NH(2)-domain in regulating relative amounts of endopin 2A that enter the substrate pathway compared to the serpin inhibitory pathway. Furthermore, site-directed mutagenesis demonstrated that the RSL domain with intact P1-P1' residues was necessary for inhibition. These findings indicate that the NH(2)-domain and the RSL region both participate in endopin 2A inhibition of papain. | lld:pubmed |
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| pubmed-article:17451636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17451636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451636 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17451636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17451636 | pubmed:month | May | lld:pubmed |
| pubmed-article:17451636 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:17451636 | pubmed:author | pubmed-author:HookVivian... | lld:pubmed |
| pubmed-article:17451636 | pubmed:author | pubmed-author:HwangShin-Ron... | lld:pubmed |
| pubmed-article:17451636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17451636 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17451636 | pubmed:volume | 461 | lld:pubmed |
| pubmed-article:17451636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17451636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17451636 | pubmed:pagination | 219-24 | lld:pubmed |
| pubmed-article:17451636 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:17451636 | pubmed:meshHeading | pubmed-meshheading:17451636... | lld:pubmed |
| pubmed-article:17451636 | pubmed:meshHeading | pubmed-meshheading:17451636... | lld:pubmed |
| pubmed-article:17451636 | pubmed:meshHeading | pubmed-meshheading:17451636... | lld:pubmed |
| pubmed-article:17451636 | pubmed:meshHeading | pubmed-meshheading:17451636... | lld:pubmed |
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| pubmed-article:17451636 | pubmed:meshHeading | pubmed-meshheading:17451636... | lld:pubmed |
| pubmed-article:17451636 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17451636 | pubmed:articleTitle | Multiple domains of endopin 2A for serpin cross-class inhibition of papain. | lld:pubmed |
| pubmed-article:17451636 | pubmed:affiliation | Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093-0744, USA. | lld:pubmed |
| pubmed-article:17451636 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17451636 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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