| pubmed-article:17451234 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17451234 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:17451234 | lifeskim:mentions | umls-concept:C0023175 | lld:lifeskim |
| pubmed-article:17451234 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:17451234 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:17451234 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:17451234 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17451234 | pubmed:dateCreated | 2007-5-10 | lld:pubmed |
| pubmed-article:17451234 | pubmed:abstractText | Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 microM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand efficient analogues using a fragment growing approach. Iterative structure-based design was supported by protein-ligand structure determinations using a PKA-PKB "chimera" and a final protein-ligand structure of a lead compound in PKBbeta itself. | lld:pubmed |
| pubmed-article:17451234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17451234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17451234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17451234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17451234 | pubmed:month | May | lld:pubmed |
| pubmed-article:17451234 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:GarrettMichel... | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:BarfordDavidD | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:WyattPaul GPG | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:DaviesThomas... | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:VerdonkMarcel... | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:BerdiniValeri... | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:WoodheadSteve... | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:BoyleRobert... | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:DownhamRobert... | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:SaxtyGordonG | lld:pubmed |
| pubmed-article:17451234 | pubmed:author | pubmed-author:CarrRobin ARA | lld:pubmed |
| pubmed-article:17451234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17451234 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:17451234 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:17451234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17451234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17451234 | pubmed:pagination | 2293-6 | lld:pubmed |
| pubmed-article:17451234 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:meshHeading | pubmed-meshheading:17451234... | lld:pubmed |
| pubmed-article:17451234 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17451234 | pubmed:articleTitle | Identification of inhibitors of protein kinase B using fragment-based lead discovery. | lld:pubmed |
| pubmed-article:17451234 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17451234 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17451234 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17451234 | lld:pubmed |
