| pubmed-article:17448998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0014139 | lld:lifeskim |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0596963 | lld:lifeskim |
| pubmed-article:17448998 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17448998 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17448998 | pubmed:dateCreated | 2007-4-23 | lld:pubmed |
| pubmed-article:17448998 | pubmed:abstractText | Diverse cell types require the ability to maintain dynamically polarized membrane-protein distributions through balancing transport and diffusion. However, design principles underlying dynamically maintained cortical polarity are not well understood. Here we constructed a mathematical model for characterizing the morphology of dynamically polarized protein distributions. We developed analytical approaches for measuring all model parameters from single-cell experiments. We applied our methods to a well-characterized system for studying polarized membrane proteins: budding yeast cells expressing activated Cdc42. We found that a balance of diffusion, directed transport, and endocytosis was sufficient for accurately describing polarization morphologies. Surprisingly, the model predicts that polarized regions are defined with a precision that is nearly optimal for measured endocytosis rates and that polarity can be dynamically stabilized through positive feedback with directed transport. Our approach provides a step toward understanding how biological systems shape spatially precise, unambiguous cortical polarity domains using dynamic processes. | lld:pubmed |
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| pubmed-article:17448998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17448998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17448998 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17448998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17448998 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17448998 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:17448998 | pubmed:author | pubmed-author:TranJ VJV | lld:pubmed |
| pubmed-article:17448998 | pubmed:author | pubmed-author:WuLani FLF | lld:pubmed |
| pubmed-article:17448998 | pubmed:author | pubmed-author:AltschulerSte... | lld:pubmed |
| pubmed-article:17448998 | pubmed:author | pubmed-author:Wedlich-Soldn... | lld:pubmed |
| pubmed-article:17448998 | pubmed:author | pubmed-author:MarcoEugenioE | lld:pubmed |
| pubmed-article:17448998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17448998 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:17448998 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:17448998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17448998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17448998 | pubmed:pagination | 411-22 | lld:pubmed |
| pubmed-article:17448998 | pubmed:dateRevised | 2011-3-23 | lld:pubmed |
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| pubmed-article:17448998 | pubmed:meshHeading | pubmed-meshheading:17448998... | lld:pubmed |
| pubmed-article:17448998 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17448998 | pubmed:articleTitle | Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. | lld:pubmed |
| pubmed-article:17448998 | pubmed:affiliation | Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. | lld:pubmed |
| pubmed-article:17448998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17448998 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17448998 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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