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pubmed-article:1743918pubmed:dateCreated1992-1-16lld:pubmed
pubmed-article:1743918pubmed:abstractTextBioabsorption of synthetic apatite compounds used to promote bone healing and remodeling has been difficult to evaluate. In this study, solid-state phosphorus-31 nuclear magnetic resonance (NMR) has been used to characterize and quantitate bone mineral and a synthetic apatite in order to establish a model for bioabsorption studies. Pulverized solid samples of cortical rabbit bone and a synthetic fluoridated apatite were examined in vitro at variable degrees of hydration. A 9.4 T superconducting spectrometer was used to obtain 31P magic angle spinning NMR spectra and T1 relaxation times. Quantitation was attempted in mixed samples using T1 recovery data. Bone mineral and synthetic apatite could be distinguished by chemical shift and T1 relaxation time in variable hydration states, and were readily differentiated in mixtures by their T1 relaxation time. NMR estimates of relative proportions of components in mixed samples were accurate within 2% of evaluations based on weight. Solid-state 31P NMR therefore provides a suitable method for monitoring the bioabsorption of synthetic apatites.lld:pubmed
pubmed-article:1743918pubmed:languageenglld:pubmed
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pubmed-article:1743918pubmed:statusMEDLINElld:pubmed
pubmed-article:1743918pubmed:monthNovlld:pubmed
pubmed-article:1743918pubmed:issn0020-9996lld:pubmed
pubmed-article:1743918pubmed:authorpubmed-author:YoungS WSWlld:pubmed
pubmed-article:1743918pubmed:authorpubmed-author:DawsonK LKLlld:pubmed
pubmed-article:1743918pubmed:authorpubmed-author:FarnanI EIElld:pubmed
pubmed-article:1743918pubmed:authorpubmed-author:ConstantzB...lld:pubmed
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pubmed-article:1743918pubmed:volume26lld:pubmed
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pubmed-article:1743918pubmed:pagination946-50lld:pubmed
pubmed-article:1743918pubmed:dateRevised2009-11-11lld:pubmed
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pubmed-article:1743918pubmed:year1991lld:pubmed
pubmed-article:1743918pubmed:articleTitleSolid-state phosphorus-31 nuclear magnetic resonance differentiation of bone mineral and synthetic apatite used to fill bone defects.lld:pubmed
pubmed-article:1743918pubmed:affiliationDepartment of Diagnostic Radiology, Stanford University School of Medicine, California 94305.lld:pubmed
pubmed-article:1743918pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1743918pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:1743918pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed