| pubmed-article:17425295 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C1149098 | lld:lifeskim |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:17425295 | lifeskim:mentions | umls-concept:C0887819 | lld:lifeskim |
| pubmed-article:17425295 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:17425295 | pubmed:dateCreated | 2007-4-26 | lld:pubmed |
| pubmed-article:17425295 | pubmed:abstractText | Presentation of (glyco)peptides by the class II major histocompatibility complex molecule Aq to T cells plays a central role in collagen-induced arthritis, an animal model for the autoimmune disease rheumatoid arthritis. A peptide library was designed using statistical molecular design in amino acid space in which five positions in the minimal mouse collagen type II binding epitope CII260-267 were varied. A substantially reduced peptide library of 24 peptides with diverse and representative molecular characteristics was selected, synthesized, and evaluated for the binding strength to Aq. A multivariate QSAR model was established by correlating calculated descriptors, compressed to its principle properties, with the binding data using partial least-square regression. The model was successfully validated by an external test set. Interpretation of the model provided a molecular property binding motif for peptides interacting with Aq. The information may be useful in future research directed toward new treatments of rheumatoid arthritis. | lld:pubmed |
| pubmed-article:17425295 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17425295 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17425295 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17425295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17425295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17425295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17425295 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17425295 | pubmed:month | May | lld:pubmed |
| pubmed-article:17425295 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:17425295 | pubmed:author | pubmed-author:HolmdahlRikar... | lld:pubmed |
| pubmed-article:17425295 | pubmed:author | pubmed-author:KihlbergJanJ | lld:pubmed |
| pubmed-article:17425295 | pubmed:author | pubmed-author:HolmLottaL | lld:pubmed |
| pubmed-article:17425295 | pubmed:author | pubmed-author:DzhambazovBal... | lld:pubmed |
| pubmed-article:17425295 | pubmed:author | pubmed-author:LinussonAnnaA | lld:pubmed |
| pubmed-article:17425295 | pubmed:author | pubmed-author:FrechKristina... | lld:pubmed |
| pubmed-article:17425295 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17425295 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:17425295 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:17425295 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17425295 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17425295 | pubmed:pagination | 2049-59 | lld:pubmed |
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| pubmed-article:17425295 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17425295 | pubmed:articleTitle | Quantitative structure-activity relationship of peptides binding to the class II major histocompatibility complex molecule Aq associated with autoimmune arthritis. | lld:pubmed |
| pubmed-article:17425295 | pubmed:affiliation | Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden. | lld:pubmed |
| pubmed-article:17425295 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17425295 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17425295 | lld:chembl |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17425295 | lld:pubmed |
