| pubmed-article:17417702 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17417702 | lifeskim:mentions | umls-concept:C0969702 | lld:lifeskim |
| pubmed-article:17417702 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:17417702 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:17417702 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17417702 | pubmed:dateCreated | 2007-4-18 | lld:pubmed |
| pubmed-article:17417702 | pubmed:abstractText | The Na(+)-dependent transport of neutral amino acids in epithelial cells and neurons is mediated by B(0)-type neutral amino acid transporters. Two B(0)-type amino acid transporters have been identified in the neurotransmitter transporter family SLC6, namely B(0)AT1 (SLC6A19) and B(0)AT2 (SLC6A15). In contrast to other members of this family, B(0)-like transporters are chloride-independent. B(0)AT1 and B(0)AT2 preferentially bind the substrate prior to the Na(+)-ion. The Na(+)-concentration affects the K ( m ) of the substrate and vice versa. A kinetic scheme is proposed that is consistent with the experimental data. An overlapping binding site of substrate and cosubstrate has been demonstrated in the bacterial orthologue LeuT( Aa ) from Aquifex aeolicus, which elegantly explains the mutual effect of substrate and cosubstrate on each other's K ( m )-value. LeuT( Aa ) is sequence-related to transporters of the SLC6 family, allowing homology modeling of B(0)-like transporters along its structure. | lld:pubmed |
| pubmed-article:17417702 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17417702 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417702 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17417702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417702 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17417702 | pubmed:issn | 0022-2631 | lld:pubmed |
| pubmed-article:17417702 | pubmed:author | pubmed-author:OakleyAA | lld:pubmed |
| pubmed-article:17417702 | pubmed:author | pubmed-author:BröerSS | lld:pubmed |
| pubmed-article:17417702 | pubmed:author | pubmed-author:O'MaraMM | lld:pubmed |
| pubmed-article:17417702 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17417702 | pubmed:volume | 213 | lld:pubmed |
| pubmed-article:17417702 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17417702 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17417702 | pubmed:pagination | 111-8 | lld:pubmed |
| pubmed-article:17417702 | pubmed:meshHeading | pubmed-meshheading:17417702... | lld:pubmed |
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| pubmed-article:17417702 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17417702 | pubmed:articleTitle | Mechanism and putative structure of B(0)-like neutral amino acid transporters. | lld:pubmed |
| pubmed-article:17417702 | pubmed:affiliation | Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, Alberta, Canada, T2N 1N4. | lld:pubmed |
| pubmed-article:17417702 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17417702 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17417702 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:17417702 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17417702 | lld:pubmed |
