| pubmed-article:17417655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17417655 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17417655 | lifeskim:mentions | umls-concept:C1156210 | lld:lifeskim |
| pubmed-article:17417655 | lifeskim:mentions | umls-concept:C2699123 | lld:lifeskim |
| pubmed-article:17417655 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17417655 | pubmed:dateCreated | 2007-5-2 | lld:pubmed |
| pubmed-article:17417655 | pubmed:abstractText | Human RAD51 and RAD54 are key players in homologous recombination, a process that requires homology recognition and strand invasion by a RAD51-single-stranded DNA (ssDNA) nucleoprotein filament and chromatin remodeling by RAD54. Here we use in vitro chromatin reconstitution systems to show that RAD51-ssDNA stimulates RAD54-dependent chromatin remodeling in a homology-dependent, polarity-independent manner. This stimulation was not seen with RAD54B or other remodelers. Chromatin remodeling by RAD54 enabled strand invasion by RAD51-ssDNA on nucleosomal templates, which was homology- and polarity-dependent. Three natural RAD54 mutants found in primary cancer cells showed specific defects in remodeling or in the RAD54-RAD51 interaction. We propose that RAD54 is recruited by RAD51-ssDNA filament to the chromatin of the intact chromosome and that it remodels that chromatin to facilitate accessibility for strand exchange. | lld:pubmed |
| pubmed-article:17417655 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17417655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17417655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17417655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17417655 | pubmed:month | May | lld:pubmed |
| pubmed-article:17417655 | pubmed:issn | 1545-9993 | lld:pubmed |
| pubmed-article:17417655 | pubmed:author | pubmed-author:KingstonRober... | lld:pubmed |
| pubmed-article:17417655 | pubmed:author | pubmed-author:FanHua-YingHY | lld:pubmed |
| pubmed-article:17417655 | pubmed:author | pubmed-author:GoldmanJoseph... | lld:pubmed |
| pubmed-article:17417655 | pubmed:author | pubmed-author:ZhangZhaoqing... | lld:pubmed |
| pubmed-article:17417655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17417655 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:17417655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17417655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17417655 | pubmed:pagination | 397-405 | lld:pubmed |
| pubmed-article:17417655 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17417655 | pubmed:meshHeading | pubmed-meshheading:17417655... | lld:pubmed |
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| pubmed-article:17417655 | pubmed:meshHeading | pubmed-meshheading:17417655... | lld:pubmed |
| pubmed-article:17417655 | pubmed:meshHeading | pubmed-meshheading:17417655... | lld:pubmed |
| pubmed-article:17417655 | pubmed:meshHeading | pubmed-meshheading:17417655... | lld:pubmed |
| pubmed-article:17417655 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17417655 | pubmed:articleTitle | Homology-driven chromatin remodeling by human RAD54. | lld:pubmed |
| pubmed-article:17417655 | pubmed:affiliation | Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA. | lld:pubmed |
| pubmed-article:17417655 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17417655 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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