pubmed-article:17412961 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1167167 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C0162797 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1423492 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C0205199 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1710360 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
pubmed-article:17412961 | lifeskim:mentions | umls-concept:C1321560 | lld:lifeskim |
pubmed-article:17412961 | pubmed:issue | 5821 | lld:pubmed |
pubmed-article:17412961 | pubmed:dateCreated | 2007-4-6 | lld:pubmed |
pubmed-article:17412961 | pubmed:abstractText | Although highly homologous, the spliceosomal hPrp31 and the nucleolar Nop56 and Nop58 (Nop56/58) proteins recognize different ribonucleoprotein (RNP) particles. hPrp31 interacts with complexes containing the 15.5K protein and U4 or U4atac small nuclear RNA (snRNA), whereas Nop56/58 associate with 15.5K-box C/D small nucleolar RNA complexes. We present structural and biochemical analyses of hPrp31-15.5K-U4 snRNA complexes that show how the conserved Nop domain in hPrp31 maintains high RNP binding selectivity despite relaxed RNA sequence requirements. The Nop domain is a genuine RNP binding module, exhibiting RNA and protein binding surfaces. Yeast two-hybrid analyses suggest a link between retinitis pigmentosa and an aberrant hPrp31-hPrp6 interaction that blocks U4/U6-U5 tri-snRNP formation. | lld:pubmed |
pubmed-article:17412961 | pubmed:language | eng | lld:pubmed |
pubmed-article:17412961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17412961 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:17412961 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17412961 | pubmed:month | Apr | lld:pubmed |
pubmed-article:17412961 | pubmed:issn | 1095-9203 | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:LiPingP | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:LührmannReinh... | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:LiuSunbinS | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:CarlomagnoTer... | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:HartmuthKlaus... | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:WahlMarkus... | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:NottrottSteph... | lld:pubmed |
pubmed-article:17412961 | pubmed:author | pubmed-author:DybkovOlexand... | lld:pubmed |
pubmed-article:17412961 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:17412961 | pubmed:day | 6 | lld:pubmed |
pubmed-article:17412961 | pubmed:volume | 316 | lld:pubmed |
pubmed-article:17412961 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17412961 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17412961 | pubmed:pagination | 115-20 | lld:pubmed |
pubmed-article:17412961 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:17412961 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17412961 | pubmed:articleTitle | Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. | lld:pubmed |
pubmed-article:17412961 | pubmed:affiliation | Abteilung Zelluläre Biochemie, Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg 11, D-37077 Göttingen, Germany. | lld:pubmed |
pubmed-article:17412961 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17412961 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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