Linked Life Data

17408460

Source:http://linkedlifedata.com/resource/pubmed/id/17408460

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pubmed-article:17408460pubmed:abstractTextStage I/IIA follicular lymphoma (FL) is considered a localised disease that can be adequately treated with radiotherapy alone. Bone marrow (BM) and peripheral blood (PB) involvement in FL was investigated by polymerase chain reaction (PCR) in a series of 24 consecutive patients with histologically revised diagnosis and treated with involved field radiotherapy. Despite the limited stage, Bcl-2/IgH+ cells were found at diagnosis in PB and/or BM of 16 patients (66.6%). After treatment, in 9/15 Bcl-2/IgH positive evaluable patients, a disappearance of Bcl-2/IgH+ cells was observed, which persisted after a median follow-up of 43.5 months (range 11-70) in all but one patient. Quantitative PCR demonstrated the feasibility of clearing PB and BM Bcl-2+ cells after local irradiation of the primary site of the disease only when the basal number of lymphoma cells was <1:100 000. Patients with Bcl-2/IgH+ cells at diagnosis or after treatment had a higher likelihood of relapse. Thus, despite a negative BM biopsy, the majority of localised FL Bcl-2/IgH+ cells were found in the PB and BM. Lymphoma cells can reversibly spread from the affected lymph node to PB and BM and, in a proportion of cases, durably disappear after irradiation. The possibility of a persistent lymphoma cell clearance is proportional to the amount of cells detected at presentation by quantitative PCR.lld:pubmed
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pubmed-article:17408460pubmed:year2007lld:pubmed
pubmed-article:17408460pubmed:articleTitleStage I/II follicular lymphoma: spread of bcl-2/IgH+ cells in blood and bone marrow from primary site of disease and possibility of clearance after involved field radiotherapy.lld:pubmed
pubmed-article:17408460pubmed:affiliationDivision of Haematology, Dipartimento di Biotecnologie Cellulari ed Ematologia, "La Sapienza" University, Rome, Italy. masa.pth2@tmd.ac.jplld:pubmed
pubmed-article:17408460pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17408460pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed