Transcranial Doppler to evaluate the effects of antihypertensive medication on cerebral blood flow velocity.

Source:http://linkedlifedata.com/resource/pubmed/id/1740539

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Authors

Bindlish V, Ramadan NM, Robert S, Fagan SC, Steigerwalt SP

Affiliation

College of Pharmacy, Wayne State University, Detroit, MI 48202.

Abstract

The effect of oral nifedipine on cerebral blood flow velocity was studied in six elderly hypertensive patients using transcranial Doppler. Serial measurements of blood pressure (BP), middle cerebral artery (MCA) flow velocity and nifedipine serum concentrations were obtained over an 8-hour period. The authors found a significant inverse relationship between MCA velocities and nifedipine concentrations, independent of BP changes. These results are consistent with a direct vasodilatory effect of nifedipine on cerebral vessels and support the use of TCD in pharmacodynamic investigations of the cerebral vasculature.

PMID
1740539

MESH Terms

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