pubmed-article:17400799 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17400799 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:17400799 | lifeskim:mentions | umls-concept:C0014272 | lld:lifeskim |
pubmed-article:17400799 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
pubmed-article:17400799 | lifeskim:mentions | umls-concept:C0034843 | lld:lifeskim |
pubmed-article:17400799 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
pubmed-article:17400799 | lifeskim:mentions | umls-concept:C1135764 | lld:lifeskim |
pubmed-article:17400799 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
pubmed-article:17400799 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:17400799 | pubmed:dateCreated | 2007-4-2 | lld:pubmed |
pubmed-article:17400799 | pubmed:abstractText | It is well known that thyroid hormone affects body composition; however, the effect of the thyroid hormone receptor beta (TRbeta)-selective thyromimetic GC-1 on this biological feature had not been demonstrated. In the current study, we compared the effects of a 6-week treatment with triiodothyronine (T3; daily injections of 3 or 6 microg/100 g body weight) or GC-1 (equimolar doses) on different metabolic parameters in adult female rats. Whereas all animals gained weight (17-25 g) in a way not basically affected by T3 or GC-1 treatment, only T3 treatment selectively increased food intake (50-70%). Oxygen consumption was significantly and equally increased (50-70%) by T3 and GC-1. Analysis of body composition by dual-energy X-ray absorptiometry (DEXA) revealed that, whereas control animals gained about 80% of fat mass, T3- or GC-1-treated animals lost 70-90 and approximately 20% respectively. Direct analysis of the carcass showed that T3 treatment promoted a 14-74% decrease in fat content but GC-1 treatment promoted only a 15-23% reduction. The gain in lean mass by DEXA and the carcass protein content were not affected by T3 or GC-1 treatment. However, the mass of individual skeletal muscles was negatively affected by T3 but only barely by GC-1. These findings highlight the potential use of GC-1 for the treatment of obesity and the metabolic syndrome. | lld:pubmed |
pubmed-article:17400799 | pubmed:language | eng | lld:pubmed |
pubmed-article:17400799 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17400799 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17400799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:17400799 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17400799 | pubmed:month | Apr | lld:pubmed |
pubmed-article:17400799 | pubmed:issn | 0022-0795 | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:ScanlanThomas... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:BiancoAntonio... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:FreitasFatima... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:MoriscotAnsel... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:AokiMarcelo... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:RibeiroMiriam... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:GouveiaCecíli... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:VillicevCássi... | lld:pubmed |
pubmed-article:17400799 | pubmed:author | pubmed-author:TaffarelCássi... | lld:pubmed |
pubmed-article:17400799 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17400799 | pubmed:volume | 193 | lld:pubmed |
pubmed-article:17400799 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17400799 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17400799 | pubmed:pagination | 21-9 | lld:pubmed |
pubmed-article:17400799 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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pubmed-article:17400799 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17400799 | pubmed:articleTitle | Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. | lld:pubmed |
pubmed-article:17400799 | pubmed:affiliation | Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil. | lld:pubmed |
pubmed-article:17400799 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17400799 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:17400799 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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