| pubmed-article:1739748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C0009002 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C0015686 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C0030011 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:1739748 | lifeskim:mentions | umls-concept:C1158365 | lld:lifeskim |
| pubmed-article:1739748 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1739748 | pubmed:dateCreated | 1992-3-23 | lld:pubmed |
| pubmed-article:1739748 | pubmed:abstractText | The effects of clofibrate feeding on the metabolism of polyunsaturated fatty acids were studied in isolated rat hepatocytes. Administration of clofibrate stimulated the oxidation and particularly the peroxisomal beta-oxidation of all the fatty acids used. The increase in oxidation products was markedly higher when n-3 fatty acids were used as substrate, indicating that peroxisomes contribute more to the oxidation of n-3 than n-6 fatty acids. The whole increase in oxidation could be accounted for by a corresponding decrease in acylation in triacylglycerol while the esterification in phospholipids remained unchanged. A marked stimulation of the amounts of newly synthesized C16 and C18 fatty acids recovered, was observed when 18:2(n-6), 20:3(n-6), 18:3 (n-3) and 20:5(n-3), but not when 20:4(n-6) and 22:4(n-6) were used as substrate. This agrees with the view that extra-mitochondrial acetyl-CoA produced from peroxisomal beta-oxidation is more easily used for fatty acid new synthesis than acetyl-CoA from mitochondrial beta-oxidation. The delta 6 and delta 5 desaturase activities were distinctly higher in cells from clofibrate fed rats indicating a stimulating effect. | lld:pubmed |
| pubmed-article:1739748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1739748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739748 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1739748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1739748 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1739748 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:1739748 | pubmed:author | pubmed-author:ChristensenEE | lld:pubmed |
| pubmed-article:1739748 | pubmed:author | pubmed-author:GrønnMM | lld:pubmed |
| pubmed-article:1739748 | pubmed:author | pubmed-author:Christopherse... | lld:pubmed |
| pubmed-article:1739748 | pubmed:author | pubmed-author:HagveT ATA | lld:pubmed |
| pubmed-article:1739748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1739748 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:1739748 | pubmed:volume | 1123 | lld:pubmed |
| pubmed-article:1739748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1739748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1739748 | pubmed:pagination | 170-6 | lld:pubmed |
| pubmed-article:1739748 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:meshHeading | pubmed-meshheading:1739748-... | lld:pubmed |
| pubmed-article:1739748 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1739748 | pubmed:articleTitle | Effects of clofibrate feeding on essential fatty acid desaturation and oxidation in isolated rat liver cells. | lld:pubmed |
| pubmed-article:1739748 | pubmed:affiliation | Institute for Clinical Biochemistry, University of Oslo, Norway. | lld:pubmed |
| pubmed-article:1739748 | pubmed:publicationType | Journal Article | lld:pubmed |
