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pubmed-article:17387949pubmed:abstractTextEight rhesus monkeys (Macaca mulatta) were whole-body irradiated with 6000 rads of 32-MeV protons. Animals were killed at several time intervals after exposure. Tissue blocks were fixed in glutaraldehyde, post-osmicated, and then embedded in Maraglas-D.E.R. 732 resin. Observation of ultrathin sections by electron microscopy revealed balloon-like enlargements of distal portions of hepatocytic microvilli (blebs) which were less dense than the proximal portion of microvilli. The blebs ranged widely in size; some were contained within the space of Disse, whereas many protruded into the sinusoidal lumen. In a few micrographs the sinusoidal lumen as filled with bleb-like structures. Such bleb formation suggests a possible mechanistic explanation for hepatic congestion following high levels of irradiation.lld:pubmed
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pubmed-article:17387949pubmed:authorpubmed-author:ThomasHHlld:pubmed
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pubmed-article:17387949pubmed:dateRevised2007-12-3lld:pubmed
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pubmed-article:17387949pubmed:articleTitleMicrovillar bleb formation in primate hepatocytes irradiated with 32-meV protons.lld:pubmed
pubmed-article:17387949pubmed:affiliationLaboratory of Experimental Pathology, Department of Pathology, Baylor University College of Medicine, Houston, Texas, USA.lld:pubmed
pubmed-article:17387949pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17387949pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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