| pubmed-article:17375046 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17375046 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:17375046 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17375046 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:17375046 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:17375046 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17375046 | pubmed:dateCreated | 2007-4-17 | lld:pubmed |
| pubmed-article:17375046 | pubmed:abstractText | Growth of human tumours depends on the supply of oxygen and nutrients via the surrounding vasculature. Therefore tumour vasculature is an attractive target for anticancer therapy. Apart from angiogenesis inhibitors that compromise the formation of new blood vessels, a second class of specific anticancer drugs has been developed. These so-called vascular disrupting agents (VDAs) target the established tumour vasculature and cause an acute and pronounced shutdown of blood vessels resulting in an almost complete stop of blood flow, ultimately leading to selective tumour necrosis. As a number of VDAs are now being tested in clinical studies, we will discuss their mechanism of action and the results obtained in preclinical studies. Also data from clinical studies will be reviewed and some considerations with regard to the future development are given. | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17375046 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17375046 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17375046 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17375046 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:17375046 | pubmed:author | pubmed-author:HinnenPP | lld:pubmed |
| pubmed-article:17375046 | pubmed:author | pubmed-author:EskensF A L... | lld:pubmed |
| pubmed-article:17375046 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17375046 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:17375046 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:17375046 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17375046 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17375046 | pubmed:pagination | 1159-65 | lld:pubmed |
| pubmed-article:17375046 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:meshHeading | pubmed-meshheading:17375046... | lld:pubmed |
| pubmed-article:17375046 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17375046 | pubmed:articleTitle | Vascular disrupting agents in clinical development. | lld:pubmed |
| pubmed-article:17375046 | pubmed:affiliation | Department of Medical Oncology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands. | lld:pubmed |
| pubmed-article:17375046 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17375046 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17375046 | lld:pubmed |
