| pubmed-article:17371946 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0115305 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C1171318 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17371946 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17371946 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17371946 | pubmed:dateCreated | 2007-7-3 | lld:pubmed |
| pubmed-article:17371946 | pubmed:abstractText | E-selectin is a major adhesion molecule expressed by endothelial cells (ECs), which are exposed to shear stress and neighboring smooth muscle cells (SMCs). We investigated the mechanisms underlying the modulation of EC E-selectin expression by SMCs and shear stress. SMC coculture induced rapid and sustained increases in expression of E-selectin and phosphorylation of interleukin-1 (IL-1) receptor-associated kinase glycoprotein-130, as well as the downstream mitogen-activated protein kinases (MAPKs) and Akt. By using specific inhibitors, dominant-negative mutants, and small interfering RNA, we demonstrated that activations of c-Jun-NH(2)-terminal kinase (JNK) and p38 of the MAPK pathways are critical for the coculture-induced E-selectin expression. Gel shifting and chromatin immunoprecipitation assays showed that SMC coculture increased the nuclear factor-kappaB (NF-kappaB)-promoter binding activity in ECs; inhibition of NF-kappaB activation by p65-antisense, lactacystin, and N-acetyl-cysteine blocked the coculture-induced E-selectin promoter activity. Protein arrays and blocking assays using neutralizing antibodies demonstrated that IL-1beta and IL-6 produced by EC/SMC cocultures are major contributors to the coculture induction of EC signaling and E-selectin expression. Preshearing of ECs at 12 dynes/cm(2) inhibited the coculture-induced EC signaling and E-selectin expression. Our findings have elucidated the molecular mechanisms underlying the SMC induction of EC E-selectin expression and the shear stress protection against this SMC induction. | lld:pubmed |
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| pubmed-article:17371946 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17371946 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17371946 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17371946 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17371946 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17371946 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:ChienShuS | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:UsamiShunichi... | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:ChiuJeng-Jian... | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:LeePei-LingPL | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:LeeChih-ICI | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:ChenLi-JingLJ | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:LinChia-WenCW | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:TsaiMin-Chien... | lld:pubmed |
| pubmed-article:17371946 | pubmed:author | pubmed-author:LeeDing-YuDY | lld:pubmed |
| pubmed-article:17371946 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17371946 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17371946 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:17371946 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17371946 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17371946 | pubmed:pagination | 519-28 | lld:pubmed |
| pubmed-article:17371946 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17371946 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17371946 | pubmed:articleTitle | Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. | lld:pubmed |
| pubmed-article:17371946 | pubmed:affiliation | Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China. jjchiu@nhri.org.tw | lld:pubmed |
| pubmed-article:17371946 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17371946 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17371946 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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