| pubmed-article:17368566 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17368566 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:17368566 | lifeskim:mentions | umls-concept:C1414376 | lld:lifeskim |
| pubmed-article:17368566 | lifeskim:mentions | umls-concept:C1314889 | lld:lifeskim |
| pubmed-article:17368566 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17368566 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17368566 | pubmed:dateCreated | 2007-4-5 | lld:pubmed |
| pubmed-article:17368566 | pubmed:abstractText | Enhanced expression of valosin-containing protein (VCP) correlates with invasion and metastasis of cancers. To clarify the transcription mechanism of VCP, human and mouse genomic sequence was compared, revealing a 260 bp DNA sequence in the 5'-flanking region of VCP gene to be highly conserved between the two, in which binding motif of E74-like factor 2/new Ets-related factor (ELF2/NERF) was identified. Chromatin immunoprecipitation assay showed binding of ELF2/NERF to the 5'-flanking region of VCP gene. Knock-down of ELF2/NERF by siRNA decreased expression level of VCP. Viability of cells under tumor necrosis factor-alpha treatment significantly reduced in ELF2/NERF-knock-down breast cancer cell line. Immunohistochemical analysis on clinical breast cancer specimens showed a correlation of nuclear ELF2/NERF expression with VCP expression and proliferative activity of cells shown by Ki-67 immunohistochemistry. These findings indicate that ELF2/NERF promotes VCP transcription and that ELF2/NERF-VCP pathway might be important for cell survival and proliferation under cytokine stress. | lld:pubmed |
| pubmed-article:17368566 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17368566 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17368566 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17368566 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17368566 | pubmed:month | May | lld:pubmed |
| pubmed-article:17368566 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:17368566 | pubmed:author | pubmed-author:MoriiEiichiE | lld:pubmed |
| pubmed-article:17368566 | pubmed:author | pubmed-author:NoguchiShinza... | lld:pubmed |
| pubmed-article:17368566 | pubmed:author | pubmed-author:TomitaYasuhik... | lld:pubmed |
| pubmed-article:17368566 | pubmed:author | pubmed-author:AozasaKatsuyu... | lld:pubmed |
| pubmed-article:17368566 | pubmed:author | pubmed-author:QiuYingY | lld:pubmed |
| pubmed-article:17368566 | pubmed:author | pubmed-author:ZhangBinglinB | lld:pubmed |
| pubmed-article:17368566 | pubmed:author | pubmed-author:HeJuxiangJ | lld:pubmed |
| pubmed-article:17368566 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17368566 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:17368566 | pubmed:volume | 356 | lld:pubmed |
| pubmed-article:17368566 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17368566 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17368566 | pubmed:pagination | 536-41 | lld:pubmed |
| pubmed-article:17368566 | pubmed:dateRevised | 2009-9-3 | lld:pubmed |
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| pubmed-article:17368566 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17368566 | pubmed:articleTitle | E74-like factor 2 regulates valosin-containing protein expression. | lld:pubmed |
| pubmed-article:17368566 | pubmed:affiliation | Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:17368566 | pubmed:publicationType | Journal Article | lld:pubmed |
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