| pubmed-article:17363677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C0043047 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C0005682 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C0018338 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C0311417 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17363677 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17363677 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17363677 | pubmed:dateCreated | 2007-7-4 | lld:pubmed |
| pubmed-article:17363677 | pubmed:abstractText | PGE(2) is a well-known inhibitor of the antidiuretic hormone-induced increase of osmotic water permeability (OWP) in different osmoregulatory epithelia; however, the mechanisms underlying this effect of PGE(2) are not completely understood. Here, we report that, in the frog Rana temporaria urinary bladder, EP(1)-receptor-mediated inhibition of arginine-vasotocin (AVT)-induced OWP by PGE(2) is attributed to increased generation of nitric oxide (NO) in epithelial cells. It was shown that the inhibitory effect of 17-phenyl-trinor-PGE(2) (17-ph-PGE(2)), an EP(1) agonist, on AVT-induced OWP was significantly reduced in the presence of 7-nitroindazole (7-NI), a neuronal NO synthase (nNOS) inhibitor. NO synthase (NOS) activity in both lysed and intact epithelial cells measured as a rate of conversion of l-[(3)H]arginine to l-[(3)H]citrulline was Ca(2+) dependent and inhibited by 7-NI. PGE(2) and 17-ph-PGE(2), but not M&B-28767 (EP(3) agonist) or butaprost (EP(2) agonist), stimulated NOS activity in epithelial cells. The above effect of PGE(2) was abolished in the presence of SC-19220, an EP(1) antagonist. 7-NI reduced the stimulatory effect of 17-ph-PGE(2) on NOS activity. 17-ph-PGE(2) increased intracellular Ca(2+) concentration and cGMP in epithelial cells. Western blot analysis revealed an nNOS expression in epithelial cells. These results show that the inhibitory effect of PGE(2) on AVT-induced OWP in the frog urinary bladder is based at least partly on EP(1)-receptor-mediated activation of the NO/cGMP pathway, suggesting a novel cross talk between AVT, PGE(2), and nNOS that may be important in the regulation of water transport. | lld:pubmed |
| pubmed-article:17363677 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17363677 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17363677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17363677 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17363677 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:17363677 | pubmed:author | pubmed-author:GambaryanStep... | lld:pubmed |
| pubmed-article:17363677 | pubmed:author | pubmed-author:BachteevaVera... | lld:pubmed |
| pubmed-article:17363677 | pubmed:author | pubmed-author:FockEkaterina... | lld:pubmed |
| pubmed-article:17363677 | pubmed:author | pubmed-author:LavrovaElenaE | lld:pubmed |
| pubmed-article:17363677 | pubmed:author | pubmed-author:NikolaevaSvet... | lld:pubmed |
| pubmed-article:17363677 | pubmed:author | pubmed-author:ParnovaRimmaR | lld:pubmed |
| pubmed-article:17363677 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17363677 | pubmed:volume | 293 | lld:pubmed |
| pubmed-article:17363677 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17363677 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17363677 | pubmed:pagination | R528-37 | lld:pubmed |
| pubmed-article:17363677 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17363677 | pubmed:meshHeading | pubmed-meshheading:17363677... | lld:pubmed |
| pubmed-article:17363677 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17363677 | pubmed:articleTitle | Prostaglandin E2 inhibits vasotocin-induced osmotic water permeability in the frog urinary bladder by EP1-receptor-mediated activation of NO/cGMP pathway. | lld:pubmed |
| pubmed-article:17363677 | pubmed:affiliation | Laboratory of Renal Physiology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, M. Torez Avenue 44, 194223 St. Petersburg, Russia. | lld:pubmed |
| pubmed-article:17363677 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17363677 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17363677 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
