| pubmed-article:17360562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17360562 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:17360562 | lifeskim:mentions | umls-concept:C0007582 | lld:lifeskim |
| pubmed-article:17360562 | lifeskim:mentions | umls-concept:C1516670 | lld:lifeskim |
| pubmed-article:17360562 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:17360562 | lifeskim:mentions | umls-concept:C0679932 | lld:lifeskim |
| pubmed-article:17360562 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17360562 | pubmed:dateCreated | 2007-3-15 | lld:pubmed |
| pubmed-article:17360562 | pubmed:abstractText | The regulation of T cell-dendritic cell (DC) contacts during clonal expansion is poorly defined. Although optimal CD4 T cell responses require prolonged exposure to antigen (Ag), it is believed that stable T cell-DC interactions occur only during the first day of the activation process. Here we show that recently activated CD4 T cells are in fact fully competent for establishing contact with Ag-bearing DC. Using two-photon imaging, we found that whereas prolonged interactions between activated T cells and Ag-bearing DCs were infrequent at high T cell precursor frequency, they were readily observed for a period of at least 2 days when lower numbers of T cells were used. We provide evidence that, when present in high numbers, Ag-specific T cells still gained access to the DC surface but were competing for the limited number of sites on DCs with sufficient peptide-MHC complexes for the establishment of a long-lived interaction. Consistent with these findings, we showed that restoration of peptide-MHC level on DCs at late time points was sufficient to recover interactions between activated T cells and DCs. Thus, the period during which CD4 T cells continue to establish stable interactions with DCs is longer than previously thought, and its duration is dictated by both Ag levels and T cell numbers, providing a feedback mechanism for the termination of CD4 T cell responses. | lld:pubmed |
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| pubmed-article:17360562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17360562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17360562 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17360562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17360562 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17360562 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17360562 | pubmed:author | pubmed-author:BoussoPhilipp... | lld:pubmed |
| pubmed-article:17360562 | pubmed:author | pubmed-author:CelliSusannaS | lld:pubmed |
| pubmed-article:17360562 | pubmed:author | pubmed-author:SimonAurélieA | lld:pubmed |
| pubmed-article:17360562 | pubmed:author | pubmed-author:GarciaZacaria... | lld:pubmed |
| pubmed-article:17360562 | pubmed:author | pubmed-author:BeuneuHélèneH | lld:pubmed |
| pubmed-article:17360562 | pubmed:author | pubmed-author:PradelliEmman... | lld:pubmed |
| pubmed-article:17360562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17360562 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:17360562 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17360562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17360562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17360562 | pubmed:pagination | 4553-8 | lld:pubmed |
| pubmed-article:17360562 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17360562 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17360562 | pubmed:articleTitle | Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion. | lld:pubmed |
| pubmed-article:17360562 | pubmed:affiliation | Institut Pasteur, G5 Dynamiques des Réponses Immunes, F-75015 Paris, France. | lld:pubmed |
| pubmed-article:17360562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17360562 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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