| pubmed-article:17353365 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C0037140 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C0524909 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C0151763 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17353365 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17353365 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17353365 | pubmed:dateCreated | 2007-3-20 | lld:pubmed |
| pubmed-article:17353365 | pubmed:abstractText | Hepatitis B virus (HBV) causes chronic infection in more than 350 million people worldwide. It replicates in hepatocytes but is non-cytopathic; liver damage is thought to be immune mediated. Here, we investigated the role of innate immune responses in mediating liver damage in patients with chronic HBV infection. Longitudinal analysis revealed a temporal correlation between flares of liver inflammation and fluctuations in interleukin (IL)-8, interferon (IFN)-alpha, and natural killer (NK) cell expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) directly ex vivo. A cross-sectional study confirmed these findings in patients with HBV-related liver inflammation compared with healthy carriers. Activated, TRAIL-expressing NK cells were further enriched in the liver of patients with chronic HBV infection, while their hepatocytes expressed increased levels of a TRAIL death-inducing receptor. IFN-alpha concentrations found in patients were capable of activating NK cells to induce TRAIL-mediated hepatocyte apoptosis in vitro. The pathogenic potential of this pathway could be further enhanced by the ability of the IFN-alpha/IL-8 combination to dysregulate the balance of death-inducing and regulatory TRAIL receptors expressed on hepatocytes. We conclude that NK cells may contribute to liver inflammation by TRAIL-mediated death of hepatocytes and demonstrate that this non-antigen-specific mechanism can be switched on by cytokines produced during active HBV infection. | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17353365 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17353365 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17353365 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17353365 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17353365 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:AdamsDavid... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:BertolettiAnt... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:ReynoldsGaryG | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:BorrowPerseph... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:WilliamsKevin... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:MainiMala KMK | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:DunnClaireC | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:BrunettoMauri... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:LamperticoPie... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:LopesA RossAR | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:HumphreysEliz... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:Christophides... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:KennedyPatric... | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:DasAbhishekA | lld:pubmed |
| pubmed-article:17353365 | pubmed:author | pubmed-author:AffordSimonS | lld:pubmed |
| pubmed-article:17353365 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17353365 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:17353365 | pubmed:volume | 204 | lld:pubmed |
| pubmed-article:17353365 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17353365 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17353365 | pubmed:pagination | 667-80 | lld:pubmed |
| pubmed-article:17353365 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17353365 | pubmed:meshHeading | pubmed-meshheading:17353365... | lld:pubmed |
